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2049-80-1 - Diethyl allylmalonate, 96% - Allylmalonic acid diethyl ester - L02286 - Alfa Aesar

L02286 Diethyl allylmalonate, 96%

Numéro CAS
2049-80-1
Synonymes
Allylmalonic acid diethyl ester

Dimensions Prix ($) Quantité Disponibilité
25g 29,56
100g 76,84
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Diethyl allylmalonate, 96%

MDL
MFCD00009155
EINECS
218-072-9

Propriétés chimiques

Formule
C10H16O4
Poids formulaire
200.23
Point d'ébullition
222-223°
Point d'éclair
92°(197°F)
Densité
1.016
Indice de réfraction
1.4310
Solubilité
Not miscible or difficult to mix with water.

Applications

Diethyl allylmalonate is an important intermediates in syntheses of vitamins B1 and B6, barbiturates, non-steroidal anti-inflammatory agents, other numerous pharmaceuticals, agrochemicals and flavors and fragrances compounds.

Notes

Keep container tightly sealed. Store in cool, dry conditions in well sealed containers. Incompatible with oxidizing agents.

Références bibliographiques

Barry M. Trost.; Andrew H. Weiss.; Axel Jacobi von Wangelin. Dinuclear Zn-Catalyzed Asymmetric Alkynylation of Unsaturated Aldehydes. J. Am. Chem. Soc. 2006, 128 (1), 8-9.

Miwako Mori. Synthesis of Natural Products and Related Compounds using Enyne Metathesis. Advanced Synthesis & Catalysis. 2007, 349(1-2), 121-135.

Alkylation at the one available acidic hydrogen, followed by removal of the allyl group with the reagent (2-propene)Ti(O-i-Pr)2, readily prepared from Ti(O-i-Pr)4 and i-PrMgCl, gives the mono-alkyl malonate. Diethyl allylmalonate can thus be regarded as a mono-protected form of diethyl malonate: J. Org. Chem., 61, 2266 (1996):

Mentions de danger et de prudence du SGH

Mentions de danger (UE): H315-H319-H335-H227

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation. Combustible liquid.

Mentions de prudence: P210-P261-P280-P305+P351+P338-P304+P340-P362-P312-P405-P403+P233-P501a

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Call a POISON CENTER or doctor/physician if you feel unwell. Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Autres références

Beilstein
1709466
Code tarifaire harmonisé
2917.19
TSCA
Yes

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