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10147-37-2 - 2-Propanesulfonyl chloride, 97% - Isopropylsulfonyl chloride - L02431 - Alfa Aesar

L02431 2-Propanesulfonyl chloride, 97%

Numéro CAS
10147-37-2
Synonymes
Isopropylsulfonyl chloride

Dimensions Prix ($) Quantité Disponibilité
5g 36,40
25g 113,00
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2-Propanesulfonyl chloride, 97%

MDL
MFCD00007453
EINECS
233-415-2

Propriétés chimiques

Formule
(CH3)2CHSO2Cl
Poids formulaire
142.60
Point de fusion
-47°
Point d'ébullition
95°/45mm
Point d'éclair
86°(186°F)
Densité
1.273
Indice de réfraction
1.4560
Sensibilité
Moisture Sensitive
Solubilité
Reacts with water.

Applications

2-Propanesulfonyl chloride is used as a pharmaceutical intermediate. Reductive cleavage of a secondary alcohol to methylene has been achieved by reduction of the 2-propanesulfonyl ester with lithium triethylborohydride.

Notes

Keep container tightly sealed. Store in cool, dry conditions in well sealed containers. Incompatible with oxidizing agents and bases. Store under dry inert gas. It is sensitive to moisture.

Références bibliographiques

James F. King.; Joe Y. L. Lam.; Vinod Dave. tert-Butyl Cation Formation in the Hydrolysis of 2-Methyl-2-propanesulfonyl Chloride, the Simplest Tertiary Alkanesulfonyl Chloride. J. Org. Chem. 1995, 60 (9), 2831-2834.

Dennis N. Kevill.; Byoung-Chun Park.; Kyoung-Ho Park.; Malcolm J. D'Souza.; Lamia Yaakoubd.; Stacey L. Mlynarski.; Jin Burm Kyong. Rate and product studies in the solvolyses of N,N-dimethylsulfamoyl and 2-propanesulfonyl chlorides. Org. Biomol. Chem. 2006, 4(8), 1580-1586.

Reductive cleavage of a secondary alcohol to methylene has been achieved by reduction of the 2-propanesulfonyl ester with lithium triethylborohydride. Reduction of the mesylate and tosylate yielded only the starting alcohol: J. Am. Chem. Soc., 107, 4088 (1985).

Mentions de danger et de prudence du SGH

Mentions de danger (UE): H314-H318-H227

Causes severe skin burns and eye damage. Causes serious eye damage. Combustible liquid.

Mentions de prudence: P210-P260-P280-P303+P361+P353-P305+P351+P338-P301+P330+P331-P304+P340-P310-P405-P501a

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Do not breathe dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Immediately call a POISON CENTER or doctor/physician. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Autres références

Beilstein
1747497
Classe de danger
8
Groupe d'emballage
II
Code tarifaire harmonisé
2904.10
TSCA
No

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