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3173-56-6 - Benzyl isocyanate, 98% - L02633 - Alfa Aesar

L02633 Benzyl isocyanate, 98%

Numéro CAS
3173-56-6
Synonymes

Dimensions Prix ($) Quantité Disponibilité
1g 21,38
5g 60,15
25g 177,30
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Benzyl isocyanate, 98%

MDL
MFCD00009701
EINECS
221-640-9

Propriétés chimiques

Formule
C8H7NO
Poids formulaire
133.15
Point d'ébullition
53-54°/0.8mm
Point d'éclair
43°(109°F)
Densité
1.078
Indice de réfraction
1.5250
Sensibilité
Moisture Sensitive
Solubilité
It hydrolyzes with water.

Applications

Benzyl isocyanate, is used as a protected ammonia equivalent in the stereo selective ring-opening of chiral 2,3-epoxy alcohols (from Sharpless asymmetric epoxidation). The key step in the sequence involves intramolecular cyclization of the carbamate intermediate. It is also used in a multicomponent, stereospecific synthesis of 1,3-oxazinane-2,4-diones employing an Al-salph complex.

Notes

Moisture& heat Sensitive. Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Keep away from alcohols, amines.

Références bibliographiques

LL Ferstandig.; RA Scherrer. Mechanism of Isocyanate Reactions with Ethanol1. J. Am. Chem. Soc. 195981(18) , 4838-4842.

DG Hoare.; DE Koshland Jr. A procedure for the selective modification of carboxyl groups in proteins. J. Am. Chem. Soc. 196688(9) , 2057-2058.

Protected ammonia equivalent in the stereoselective ring-opening of chiral 2,3-epoxy alcohols (from Sharpless asymmetric epoxidation). The key step in the sequence involves intramolecular cyclization of the carbamate intermediate: J. Org. Chem., 50, 3752 (1985):

For general reactions of isocyanates, see Appendix 3.

Mentions de danger et de prudence du SGH

Mentions de danger (UE): H301-H330-H315-H319-H335-H334-H226

Toxic if swallowed. Fatal if inhaled. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation. May cause allergy or asthma symptoms or breathing difficulties if inhaled. Flammable liquid and vapour.

Mentions de prudence: P210-P260-P301+P310-P303+P361+P353-P304+P340-P305+P351+P338-P320-P330-P405-P501a

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Do not breathe dust/fume/gas/mist/vapours/spray. IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Specific treatment is urgent (see label). Rinse mouth. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Autres références

Beilstein
636508
Classe de danger
6.1
Groupe d'emballage
II
Code tarifaire harmonisé
2929.10
TSCA
No

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