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507-09-5 - Thioacetic acid, 97% - Thiolacetic acid - L03305 - Alfa Aesar

L03305 Thioacetic acid, 97%

Numéro CAS
507-09-5
Synonymes
Thiolacetic acid

Dimensions Prix ($) Quantité Disponibilité
25g 20,61
100g 37,90
500g 98,10
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Thioacetic acid, 97%

MDL
MFCD00004853
EINECS
208-063-8

Propriétés chimiques

Formule
C2H4OS
Poids formulaire
76.12
Point de fusion
-17°
Point d'ébullition
97°
Point d'éclair
18°(64°F)
Densité
1.068
Indice de réfraction
1.4640
Solubilité
Soluble in water. (27g/L) at 16°C.

Applications

Thioacetic acid is a reagent for introduction of the thiol group into organic molecules. It is used as flavor & Fragrance Intermediates. It is used to manufacture captopril(antihypertension) and spironolac-tone (diuretic).

Notes

Protect from heat. Store away from oxidizing agents. Incompatible with strong bases, strong oxidizing agents, metals.

Références bibliographiques

Wen Yang; Da-Ming Du. Squaramide-catalysed enantio- and diastereoselective sulfa-Michael addition of thioacetic acid to α,β-disubstituted nitroalkenes.Organic & Biomolecular Chemistry.2012, 10 (34), 6876-6884.

Libo Hu; Hui Zhu; Da-Ming Du; Jiaxi Xu. Efficient synthesis of taurine and structurally diverse substituted taurines from aziridines.Journal of Organic Chemistry.2007, 72 (12), 4543-4546.

Used in several different ways for the introduction of the thiol group: Radical addition to unactivated alkenes: J. Chem. Soc., 2123 (1951). Conjugate (Michael) addition to activated double bonds: J. Am. Chem. Soc., 77, 5144 (1955); 81, 1224 (1959). Nucleophilic displacement of halide, tosylate or acetate: J. Am. Chem. Soc., 73, 2659 (1951); Carbohydr. Res., 17, 457 (1971). Alcohols can be converted to thiol esters under Mitsunobu conditions, followed by LAH reduction to the thiol: Tetrahedron Lett., 3119 (1981).

Mentions de danger et de prudence du SGH

Mentions de danger (UE): H225-H314-H318-H302-H332-H317

Highly flammable liquid and vapour. Causes severe skin burns and eye damage. Causes serious eye damage. Harmful if swallowed. Harmful if inhaled. May cause an allergic skin reaction.

Mentions de prudence: P210-P260-P261-P280-P303+P361+P353-P305+P351+P338-P301+P330+P331-P304+P340-P405-P501a

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Do not breathe dust/fume/gas/mist/vapours/spray. Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Autres références

Merck
14,9320
Beilstein
773684
Classe de danger
3
Groupe d'emballage
II
Code tarifaire harmonisé
2930.90
TSCA
Yes
RTECS
AJ5600000

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