Consentement d'utilisation des Cookies

J'accepte Notre site sauvegarde des traceurs textes (cookies) sur votre appareil afin de vous garantir de meilleurs contenus et à des fins de collectes statistiques.Vous pouvez désactiver l'usage des cookies en changeant les paramètres de votre navigateur. En poursuivant votre navigation sur notre site sans changer vos paramètres de navigateur vous nous accordez la permission de conserver des informations sur votre appareil.

106-52-5 - 4-Hydroxy-1-methylpiperidine, 98% - 1-Methyl-4-piperidinol - L06415 - Alfa Aesar

L06415 4-Hydroxy-1-methylpiperidine, 98%

Numéro CAS
106-52-5
Synonymes
1-Methyl-4-piperidinol

Dimensions Prix ($) Quantité Disponibilité
100g 39,04
500g 138,02
Ajouter au panier Ajouter au devis en vrac Afficher l'article

4-Hydroxy-1-methylpiperidine, 98%

MDL
MFCD00006500
EINECS
203-406-8

Propriétés chimiques

Formule
C6H13NO
Poids formulaire
115.18
Point de fusion
26-30°
Point d'ébullition
198-200°
Point d'éclair
87°(188°F)
Densité
0.98
Indice de réfraction
1.4790
Sensibilité
Hygroscopic
Solubilité
Soluble in water.

Applications

4-Hydroxy-1-methylpiperidine is used as reactant for optimization of Novobiocin scaffold to product antitumor agents, substitution about the rigidifying ring for histamine H4 receptor antagonist synthesis. It is also used as a reactant in the synthesis of CaMKII, VEGFR and FGFR kinase inhibitors and Phosphoinositide-3-kinase, Protein lysine methyltransferase G9a inhibitors.

Notes

Hygroscopic. Store under dry inert gas. Store away from moisture and oxidizing agents. Incompatible with water and oxidizing agents. Store at 4°C.

Références bibliographiques

Z. Dega-Szafran; E. Dulewicz; G. Dutkiewicz; Z. Kosturkiewicz; M. Szafran. Two polymorphs of 4-hydroxy-1-methylpiperidine betaine hydrochloride studied by X-ray and DFT methods.Journal of Molecular Structure.2005,751 139-150.

Z. Dega-Szafran; G. Dutkiewicz; Z. Fojud, Z. Kosturkiewicz; M. Szafran. Ring inversion in 4-hydroxy-1-methylpiperidine betaine studied by X-ray, FTIR, 13C CP MAS NMR and DFT calculations.Journal of Molecular Structure.2009,917 76-83.

Mentions de danger et de prudence du SGH

Mentions de danger (UE): H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Mentions de prudence: P261-P280-P305+P351+P338-P304+P340-P362-P312-P321-P405-P403+P233-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Call a POISON CENTER or doctor/physician if you feel unwell. Specific treatment (see label). Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Autres références

Beilstein
103024
Code tarifaire harmonisé
2933.39
TSCA
Yes

Recommandé

Consulté récemment

Produits chimiques

Sciences de la vie

Métaux et matériaux

Catalyseurs

Analytique et matériel de laboratoire