2-Methyltetrahydrofuran acts as a solvent in organic synthesis. It is considered as a replacement for terahydrofuran due to its higher reaction temperature and easy separation after reaction. It is also useful in the electrolyte formulation for secondary lithium electrodes and as a component in alternative fuels. Further, it is used as a solvent for spectroscopic studies at -1960C. It also acts as a solvent for Grignard reagent in organometallic reactions. In addition to this, it plays an important role as a motor fuel.
Cryosolvent. Has been proposed as a chlorine-free alternative solvent to dichloromethane in two-phase, including acylation and phase transfer alkylation, reactions. The water-saturated system (ca 39 mL/L) is more polar than the dry solvent, and it forms a useful azeotrope with water (ca 9 : 1), facilitating drying: Synlett, 2353 (2003).
Phanopoulos, A.; White, A. J. P.; Long, N. J.; Miller, P. W. Catalytic Transformation of Levulinic Acid to 2-Methyltetrahydrofuran Using Ruthenium-N-Triphos Complexes. ACS Catal. 2015, 5 (4), 2500-2512.
Patankar, S. C.; Yadav, G. D. Cascade Engineered Synthesis of gama-Valerolactone, 1,4-Pentanediol, and 2-Methyltetrahydrofuran from Levulinic Acid Using Pd-Cu/ZrO2 Catalyst in Water as Solvent. ACS Sustainable Chem. Eng. 2015, 3 (11), 2619-2630.
Mentions de danger (UE): H225-H313
Highly flammable liquid and vapour. May be harmful in contact with skin.
Mentions de prudence: P210-P280a-P240-P241-P303+P361+P353-P501a
Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Wear protective gloves and eye/face protection. Ground/bond container and receiving equipment. Use explosion-proof electrical/ventilating/lighting/ equipment. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. Dispose of contents/container in accordance with local/regional/national/international regulations.