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115-20-8 - 2,2,2-Trichloroethanol, 99% - L08163 - Alfa Aesar

L08163 2,2,2-Trichloroethanol, 99%

Numéro CAS
115-20-8
Synonymes

Dimensions Prix ($) Quantité Disponibilité
5g 18,75
25g 22,68
100g 33,48
500g 133,20
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2,2,2-Trichloroethanol, 99%

MDL
MFCD00004677
EINECS
204-071-0

Propriétés chimiques

Formule
Cl3CCH2OH
Poids formulaire
149.40
Point de fusion
17-18°
Point d'ébullition
151-153°
Point d'éclair
>110°(230°F)
Densité
1.560
Indice de réfraction
1.4895
Sensibilité
Hygroscopic
Solubilité
Slightly soluble in water.

Applications

2,2,2-Trichloroethanol is used as a sedative or a hypnotic. It is an important raw material and intermediate used in Organic Synthesis, Pharmaceuticals, Agrochemicals and Dyestuff.

Notes

Hygroscopic. Store away from water and oxidizing agents. Protect from humidity and water. Incompatible with oxidizing agents, Strong acids, Strong bases, Strong reducing agents, Acid chlorides, Acid anhydrides.

Références bibliographiques

Maurice R. Eftink; James L. Zajicek; Camillo A. Ghiron. A Hydrophobic Quencher of Protein Fluorescence: 2,2,2-Trichloroethanol. Biochimica et Biophysica Acta (BBA) - Protein Structure. 1977, 491 473-481.

M. Perttilä. Vibrational spectra and normal coordinate analysis of 2,2,2-trichloroethanol and 2,2,2-trifluoroethanol. Spectrochimica Acta Part A: Molecular Spectroscopy. 1979, 35 585-592.

Carboxyl groups can be protected as their trichloroethyl esters e.g. by tosic acid-catalyzed esterification: Synthesis, 24 (1979), or DCC-DMAP: J. Am. Chem. Soc., 111, 669 (1989). For esterification of amino acids, using the active ester with 2-Hydroxypyridine, A14522, see: Synthesis, 24 (1979). Cleavage occurs with Zn in AcOH or an aqueous THF buffer under mild conditions: J. Am. Chem. Soc., 88, 852 (1966); Synthesis, 457 (1976); or with NaBH4 in DMF, catalyzed by Se: Synthesis, 693 (1989). See also Appendix 6.

Similarly, carbonyl compounds can be protected as their trichloroethyl acetals, stable to base, but readily cleaved under neutral aprotic conditions by Zn in ethyl acetate or THF: J. Org. Chem., 38, 554 (1973).

Reaction with POCl3 to give the phosphorodichloridate, followed by reaction with 3-Hydroxypropionitrile, L12570, gives 2-cyanoethyl 2,2,2-trichloroethyl phosphorochloridate, a valuable reagent, usually used without purification, for the phosphorylation of nucleosides: Synthesis, 831 (1980).

Mentions de danger et de prudence du SGH

Mentions de danger (UE): H318-H315-H302-H336

Causes serious eye damage. Causes skin irritation. Harmful if swallowed. May cause drowsiness or dizziness.

Mentions de prudence: P280-P305+P351+P338-P308+P313-P330-P501a

Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF exposed or concerned: Get medical advice/attention. Rinse mouth. Dispose of contents/container in accordance with local/regional/national/international regulations.

Autres références

Merck
14,9638
Beilstein
1697495
Code tarifaire harmonisé
2905.59
TSCA
Yes
RTECS
KM3850000

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Analytique et matériel de laboratoire