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56-92-8 - Histamine dihydrochloride, 98+% - L09198 - Alfa Aesar

L09198 Histamine dihydrochloride, 98+%

Numéro CAS
56-92-8
Synonymes

Dimensions Prix ($) Quantité Disponibilité
5g 39,80
25g 134,00
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Histamine dihydrochloride, 98+%

MDL
MFCD00012703
EINECS
200-298-4

Propriétés chimiques

Formule
C5H9N3•2HCl
Poids formulaire
184.07
Point de fusion
245-249°
Solubilité
Very soluble in water and methanol. Soluble in ethanol.

Applications

Histamine dihydrochloride has been shown to activate nitric oxide synthetase and suppress or inhibit the generation of reactive oxygen species (ROS). Inhibition of ROS by histamine dihydrochloride allows activation of T cells and NK cells by IL-2. In a rat model, histamine dihydrochloride suppressed ROS generated by Kupffer cells through the H2 histamine receptor. It is a potent vasodilator and endogenous histamine receptor agonist.

Notes

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Incompatible with strong oxidizing agents. Store away from oxidizing agents. Store at 4°C.

Références bibliographiques

Egla Yareth Bivián-Castro; Mercedes G López; Mario Pedraza-Reyes; Sylvain Bernès; Guillermo Mendoza-Díaz. Synthesis, characterization, and biological activity studies of copper(II) mixed compound with histamine and nalidixic acid.Bioinorganic Chemistry and Applications.2009, 603651.

Anna Martnera; Fredrik B Thoréna; Johan Aureliusa; Jonas Söderholma; Mats Brunea & Kristoffer Hellstrand. Immunotherapy with histamine dihydrochloride for the prevention of relapse in acute myeloid leukemia.Expert Review of Hematology.2010, 3 381-391.

Mentions de danger et de prudence du SGH

Mentions de danger (UE): H334-H315-H319-H317-H335

May cause allergy or asthma symptoms or breathing difficulties if inhaled. Causes skin irritation. Causes serious eye irritation. May cause an allergic skin reaction. May cause respiratory irritation.

Mentions de prudence: P285-P261-P280-P305+P351+P338-P304+P340-P342+P311-P362-P312-P405-P501a

In case of inadequate ventilation wear respiratory protection. Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. If experiencing respiratory symptoms: Call a POISON CENTER or doctor/physician. Take off contaminated clothing and wash before reuse. Call a POISON CENTER or doctor/physician if you feel unwell. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Autres références

Merck
14,4719
Beilstein
3624116
Code tarifaire harmonisé
2933.29
TSCA
Yes
RTECS
MS1575000

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Catalyseurs

Analytique et matériel de laboratoire