Consentement d'utilisation des Cookies

J'accepte Notre site sauvegarde des traceurs textes (cookies) sur votre appareil afin de vous garantir de meilleurs contenus et à des fins de collectes statistiques.Vous pouvez désactiver l'usage des cookies en changeant les paramètres de votre navigateur. En poursuivant votre navigation sur notre site sans changer vos paramètres de navigateur vous nous accordez la permission de conserver des informations sur votre appareil.

68957-94-8 - 1-Propylphosphonic acid cyclic anhydride, 50+% soln. in ethyl acetate - 1-Propanephosphonic acid cyclic anhydride - T3P - L11911 - Alfa Aesar

L11911 1-Propylphosphonic acid cyclic anhydride, 50+% soln. in ethyl acetate

Numéro CAS
68957-94-8
Synonymes
1-Propanephosphonic acid cyclic anhydride
T3P

Dimensions Prix ($) Quantité Disponibilité
10g 34,30
50g 102,00
Ajouter au panier Ajouter au devis en vrac Afficher l'article

1-Propylphosphonic acid cyclic anhydride, 50+% soln. in ethyl acetate

MDL
MFCD00006583
EINECS
422-210-5

Propriétés chimiques

Formule
C9H21O6P3
Poids formulaire
318.19
Point d'ébullition
77°
Point d'éclair
-3°(26°F)
Densité
1.080
Indice de réfraction
1.4190
Sensibilité
Moisture Sensitive
Solubilité
Miscible with dichloromethane, dimethyl formamide, dioxane, terahydrofuran, polar and aprotic organic solvents.

Applications

1-Propylphosphonic acid cyclic anhydride is used in the synthesis of N-acyloxythiazole-2(3H)-thiones. It is also used to promote the synthesis of hydroxamic acids from carboxylic acids. Further, it is employed as an efficient promoter for the Lossen rearrangement to synthesis urea and carbamate derivatives.

Notes

Moisture sensitive. Incompatible withstrong oxidizing agents.

Références bibliographiques

T3P is a registered trademark of Clariant Group.

Condensation agent in formation of amide and ester linkages. In peptide synthesis, gives high yields, low racemization, and minimization of side reactions without the need for additives, as well as easily removable (water soluble) by-products: Angew. Chem. Int. Ed., 19, 133 (1980). Also reported for formation of a Weinreb amide in high yield from the acid and N,O-dimethylhydroxylamine: Angew. Chem. Int. Ed., 36, 1191 (1997). Activating agent for epoxidation of alkenes, giving cis-stereoselectivity in reactions with allylic alcohols: Tetrahedron Lett., 35, 8125 (1994). For a brief reviews of the reagent, see: Synlett, 1369 (2000); 1328 (2007). For peptide reagents, see Appendix 6.

Nand, B.; Khanna, G.; Chaudhary, A.; Lumb, A.; M Khurana, J. 1, 8-Diazabicyclo [5.4. 0] undec-7-ene (DBU): A Versatile Reagent in Organic Synthesis. Curr. Org. Chem. 2015, 19 (9), 790-812

Nagendra, G.; Madhu, C.; Vishwanatha, T. M.; Sureshbabu, V. V. An expedient route for the reduction of carboxylic acids to alcohols employing 1-propanephosphonic acid cyclic anhydride as acid activator. Tetrahedron Lett. 2012, 53 (38), 5059-5063.

Mentions de danger et de prudence du SGH

Mentions de danger (UE): H225-H314-H336

Highly flammable liquid and vapour. Causes severe skin burns and eye damage. May cause drowsiness or dizziness.

Mentions de prudence: P210-P260-P261-P280-P303+P361+P353-P305+P351+P338-P301+P330+P331-P304+P340-P405-P501a

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Do not breathe dust/fume/gas/mist/vapours/spray. Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Autres références

Beilstein
5079255
Classe de danger
3
Groupe d'emballage
II
Code tarifaire harmonisé
2934.99
TSCA
No

Recommandé

  • A11670

    Bis(trimethylsilyl)carbodiimide, 97%
  • A11801

    N-Ethyldiisopropylamine, 99%
  • A12198

    Trifluoroacetic acid, 99%
  • A13828

    Dansyl chloride, 96%
  • L19271

    1-Propylphosphonic acid cyclic anhydride, 50+% soln. in DMF

Consulté récemment

Produits chimiques

Sciences de la vie

Métaux et matériaux

Catalyseurs

Analytique et matériel de laboratoire