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1445-45-0 - Trimethyl orthoacetate, 98% - 1,1,1-Trimethoxyethane - L13369 - Alfa Aesar

L13369 Trimethyl orthoacetate, 98%

Numéro de CAS
1445-45-0
Synonymes
1,1,1-Trimethoxyethane

Dimension Prix ($) Quantité Disponibilité
50ml 33,30
250ml 88,00
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Trimethyl orthoacetate, 98%

MDL
MFCD00008477
EINECS
215-892-9

Propriétés chimiques

Formule
C5H12O3
Poids formulaire
120.15
Point d'ébullition
107-109°
Point d'éclair
16°(60°F)
Densité
0.956
Indice de réfraction
1.3890
Sensibilité
Moisture Sensitive
Solubilité
It hydrolyzes in water.

Applications

Trimethyl orthoacetate is used as a diols can be protected as their 1-methoxyethylidene cyclic acetals (2-methoxy-2-methyl-1,3-dioxolanes) by acid-catalyzed exchange. It is mainly used as the chemical intermediates of the medicine. Some of the other applications includes it is mainly used as chemical intermediate of pharmaceutical and agricultural chemicals, used for compound medical intermediates of vitamin B1, vitamin A1 and sulfanilamide organism, used for dye and spices industry, Medicine, agricultural chemicals, paint additives.

Notes

Moisture Sensitive. Keep container tightly closed in a dry and well-ventilated place. Keep away from oxidizing agents. Stable under recommended storage conditions.

Références bibliographiques

HPM Fromageot.; BE Griffin.; CB Reese.; JE Sulston. The synthesis of oligoribonucleotides—III: Monoacrylation of ribonucleosides and derivativesvia orthoester exchange. Tetrahedron. 1967, 23,(5), 2315-2331.

T Yoshino.; S Imori.; H Togo. Efficient esterification of carboxylic acids and phosphonic acids with trialkyl orthoacetate in ionic liquid. Tetrahedron. 2006, 62,(6), 1309-1317.

Diols can be protected as their 1-methoxyethylidene cyclic acetals (2-methoxy-2-methyl-1,3-dioxolanes) by acid-catalyzed exchange; see, e.g.: J. Am. Chem. Soc., 95, 278 (1973). See also Triethyl­ orthoacetate, L06004.

Mentions de danger et de prudence du SGH

Mentions de danger (UE): H225-H315-H319-H335

Highly flammable liquid and vapour. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Mentions de prudence: P210-P261-P303+P361+P353-P305+P351+P338-P405-P501a

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Avoid breathing dust/fume/gas/mist/vapours/spray. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Autres références

Beilstein
1098338
Classe de danger
3
Groupe d'emballage
II
Code tarifaire harmonisé
2915.90
TSCA
Yes

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Consulté récemment

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Catalyseurs

Analytique et matériel de laboratoire