Methyl 3-bromopropionate was used in the synthesis of spiroanellated γ-lactones, pinacols and unprecedented 3-(1-hydroxycycloalkyl)-l-oxaspiro[n,m]alkan-2-ones. It can react with 2-Methyl-1H-benzoimidazole to get 1-(2-Methoxycarbonylethyl)-2-methylbenzimidazole.
Adriana Pohlmann; Vincent Schanen; Dominique Guillaume; Jean-Charles Quirion; and Henri-Philippe Husson. Efficient Synthesis of Conformationally Constrained Peptidomimetics Containing 2-Oxopiperazines1. J. Org. Chem, 1997, 62, (4), 1016-1022.
Ren?suk; Zhong Hua; Mohamed Abdou; Christoph Kratky. Samarium diiodide promoted spirolactonization of cycloalkanones. Tetrahedron. 1991, 47, (34), 7037-7044.
Mentions de danger (UE): H227-H301-H315-H319-H335
Combustible liquid. Toxic if swallowed. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Mentions de prudence: P210u-P261-P301+P310a-P305+P351+P338-P405-P501a
Avoid breathing dust/fume/gas/mist/vapours/spray. IF SWALLOWED: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.