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67843-74-7 - (S)-(+)-Epichlorohydrin, 98+% - (S)-(+)-1-Chloro-2,3-epoxypropane - L14298 - Alfa Aesar

L14298 (S)-(+)-Epichlorohydrin, 98+%

Numéro de CAS
67843-74-7
Synonymes
(S)-(+)-1-Chloro-2,3-epoxypropane

Conditionnement Prix ($) Quantité Disponibilité
1g 46,80
5g 122,00
25g 347,00
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(S)-(+)-Epichlorohydrin, 98+%

MDL
MFCD00077760

Propriétés chimiques

Formule
C3H5ClO
Poids moleculaire
92.53
Point d'ébullition
116-117°
Point d'éclair
32°(90°F)
Densité
1.180
Indice de réfraction
1.4380
Solubilité
Miscible with chloroform and methanol. Immiscible with water.

Applications

(S)-(+)-Epichlorohydrin is utilized for the synthesis of macquarimicins and hydroxyisoxazolidines and (+)-cis-sylvaticin, which is a potential antitumor agent. It is used to synthesize inhibitors of fatty acid oxidation as potential metabolic modulators. It acts as a solvent for natural and synthetic resins, gums, cellulose esters and ethers, paints, varnishes, nail enamels, lacquers and cement for celluloid. It is also used as a stabilizer and also useful as a bifunctional alkylating agent with the potential to form DNA cross-links.

Notes

Hygroscopic. Store in a cool place. Incompatible with acids, bases, ammonia, amines, sodium and sodium oxides, zinc, magnesium, aluminum and its alloys and halides.

Références bibliographiques

Xue, F.; Liu, Z. Q.; Wang, Y. J.; Zhu, H. Q.; Wan, N. W.; Zheng, Y. G. Efficient synthesis of (S)-epichlorohydrin in high yield by cascade biocatalysis with halohydrin dehalogenase and epoxide hydrolase mutants. Catal. Commun. 2015, 72, 147-149.

Gajare, V. S.; Khobare, S. R.; Malavika, B.; Rajana, N.; Rao, B. V.; Kumar, U. K. S. A short diastereoselective synthesis of cis-(2S,4S) and cis-(2R,4R)-4-hydroxyprolines. Tetrahedron Lett. 2015, 56 (24), 3743-3746.

Mentions de danger et de prudence du SGH

Mentions de danger (UE): H226-H300-H310-H330-H314-H318-H317-H350

Flammable liquid and vapour. Fatal if swallowed. Fatal in contact with skin. Fatal if inhaled. Causes severe skin burns and eye damage. Causes serious eye damage. May cause an allergic skin reaction. May cause cancer.

Mentions de prudence: P301+P310a-P303+P361+P353-P304+P340-P305+P351+P338-P320-P405-P501a

IF SWALLOWED: IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Specific treatment is urgent (see label). Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Autres références

Beilstein
1420784
Classe de danger
6.1
Groupe d'emballage
II
Code tarifaire harmonisé
2910.30
TSCA
No
RTECS
RR0427100

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