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39637-99-5 - (R)-(-)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetyl chloride, 98+% - (R)-(-)-Mosher's acid chloride - (R)-(-)-MTPA-Cl - L14325 - Alfa Aesar

L14325 (R)-(-)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetyl chloride, 98+%

Numéro CAS
39637-99-5
Synonymes
(R)-(-)-Mosher's acid chloride
(R)-(-)-MTPA-Cl

Dimensions Prix ($) Quantité Disponibilité
50mg 37,90
250mg 128,75
1g 353,29
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(R)-(-)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetyl chloride, 98+%

MDL
MFCD00044400

Propriétés chimiques

Formule
C10H8ClF3O2
Poids formulaire
252.62
Point d'ébullition
213-214°
Point d'éclair
89°(192°F)
Densité
1.353
Indice de réfraction
1.4690
Sensibilité
Moisture Sensitive
Solubilité
Sparingly miscible with water.

Applications

(R)-(-)-α-Methoxy-α-(trifluoromethyl)phenylacetyl chloride is used as a chiral acylating reagent, which is used in the resolution of amino acid enantiomers like 2,5-dimethoxy-4-methylamphetamine. It is also suitable for the determination of the optical composition of compounds extracted from biological fluids.

Notes

Moisture sensitive. Store in a cool place. Keep the container tightly closed in a dry and well-ventilated place.

Références bibliographiques

Chiral derivatization reagent for determination of enantiomeric excess of alcohols and amines by NMR: J. Am. Chem. Soc., 95, 512 (1973).

/n

Hasegawa, H.; Shinohara, Y.; Masuda, N.; Hashimoto, T.; Ichida, K. Simultaneous determination of serine enantiomers in plasma using Mosher's reagent and stable isotope dilution gas chromatography-mass spectrometry. J. Mass Spectrom. 2011, 46 (5), 502-507.

Chavda, S.; Coulbeck, E.; Dingjan, M.; Eames, J.; Motevalli, M. Probing the parallel resolution of Mosher’s acid using a combination of quasi-enantiomeric oxazolidin-2-ones. Tetrahedron: Asymmetry 2008, 19 (10), 1274-1284.

Mentions de danger et de prudence du SGH

Mentions de danger (UE): H314-H318-H227

Causes severe skin burns and eye damage. Causes serious eye damage. Combustible liquid.

Mentions de prudence: P210-P260-P280-P303+P361+P353-P305+P351+P338-P301+P330+P331-P304+P340-P310-P405-P501a

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Do not breathe dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Immediately call a POISON CENTER or doctor/physician. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Autres références

Merck
14,6280
Beilstein
3591565
Classe de danger
8
Groupe d'emballage
II
Code tarifaire harmonisé
2918.99
TSCA
No

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Consulté récemment

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Catalyseurs

Analytique et matériel de laboratoire