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63148-57-2 - Poly(methylhydrosiloxane) - Methyl hydrogen polysiloxane - PMHS - L14561 - Alfa Aesar

L14561 Poly(methylhydrosiloxane)

Numéro CAS
Methyl hydrogen polysiloxane

Dimensions Prix ($) Quantité Disponibilité
50g 24,50
250g 43,40
1000g 142,00
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Propriétés chimiques

Poids formulaire
ca 1900
Point d'éclair
Indice de réfraction
Not miscible or difficult to mix in water.


Poly(methylhydrosiloxane) is used in the reduction of esters to alcohols, catalyzed by a combination of titanocene dichloride and either n-BuLi or EtMgBr. It is a safer alternative to triethoxysilane, B22063, for reduction of phosphine oxides to phosphines, catalyzed by Ti(O-i-Pr)4. It is also used in greener amine synthesis by reductive amination as an alternative to borohydrides.


Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage. Incompatible with strong oxidizing agents, amines and bases.

Références bibliographiques

Bhanu P. S. Chauhan.; Rajesh Sardar. Self-Assembled Stable Silver Nanoclusters and Nanonecklace Formation:? Poly(methylhydrosiloxane)-Mediated One-Pot Route to Organosols. Macromolecules. 2004, 37 (14), 5136-5139.

Bhanu P.S. Chauhan.; Philip Boudjouk. New neutral carrier-type ion sensors. Crown ether derivatives of poly(methylhydrosiloxane). Tetrahedron Letters. 1999, 40 (22), 4123-4126.

Convenient reducing agent with a wide variety of applications, for example:

Reduction of esters to alcohols, catalyzed by a combination of titanocene dichloride and either n-BuLi or EtMgBr: J. Org. Chem., 59, 4323 (1994). Alternatively, in combination with Ti(O-i-Pr)4 reduces a variety of esters, generally in high yield: J. Org. Chem., 60, 7884 (1995); Synlett, 831 (1994). For one-step reductive amination of carbonyl compounds in similar fashion, see: Synlett, 1655 (2000). Reduction of esters, carboxylic acids, ketones and aldehydes can also be accomplished conveniently with TBAF as a catalyst: Synlett, 989 (1997). For asymmetric reduction of ketones catalyzed by chiral quaternary fluorides, see: Tetrahedron Lett., 38, 5857 (1997).

Low-cost, safer alternative to Triethoxysilane, B22063, for reduction of phosphine oxides to phosphines, catalyzed by Ti(O-i-Pr)4. The products may be reacted in situ with alkyl halides to give a convenient one-pot conversion of phosphine oxides to phosphonium salts: Tetrahedron Lett., 35, 625 (1994).

Amine N-oxides can be reduced in the presence of Ti(O-i-Pr)4 or Pd(0): Synlett, 349 (2002).

Pd(0)-catalyzed hydrogenolysis of alkyl and aryl halides: J. Org. Chem., 51, 734 (1986). Pd(0)-catalyzed reductive cyclization of 1,6- and 1,7-enynes to give exomethylene cyclopentanes and cyclohexanes: J. Am. Chem. Soc., 109, 3161 (1987).

Low-cost alternative to Triethyl­silane, A10320, in a one-pot aromatic acylation-reduction technique allowing alkylation of the aromatic ring without the polysubstitution and rearrangements associated with Friedel-Crafts alkylations. Acylation in the presence of AlCl3 is followed by in situ reduction with PMHS: J. Chem. Soc., Perkin 1, 1705 (1989).

For a review of PMHS, see: J. Chem. Soc., Perkin 1, 3381 (1999).

Mentions de danger et de prudence du SGH

Mentions de prudence: P260u-P201-P280-P303+P361+P353-P305+P351+P338-P301+P330+P331-P304+P340-P310a-P405-P501a

Obtain special instructions before use. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Autres références

Code tarifaire harmonisé


Consulté récemment

Produits chimiques

Sciences de la vie

Métaux et matériaux


Analytique et matériel de laboratoire