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63148-57-2 - Poly(methylhydrosiloxane) - Methyl hydrogen polysiloxane - PMHS - L14561 - Alfa Aesar

L14561 Poly(methylhydrosiloxane)

Numéro CAS
63148-57-2
Synonymes
Methyl hydrogen polysiloxane
PMHS

Dimensions Prix ($) Quantité Disponibilité
50g 25,03
250g 43,16
1000g 141,11
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Poly(methylhydrosiloxane)

MDL
MFCD00084478

Propriétés chimiques

Formule
(CH3)3SiO[(CH3)HSiO]nSi(CH3)
Poids formulaire
ca 1900
Point d'éclair
204°(399°F)
Densité
1.006
Indice de réfraction
1.3980
Solubilité
Not miscible or difficult to mix in water.

Applications

Poly(methylhydrosiloxane) is used in the reduction of esters to alcohols, catalyzed by a combination of titanocene dichloride and either n-BuLi or EtMgBr. It is a safer alternative to triethoxysilane, B22063, for reduction of phosphine oxides to phosphines, catalyzed by Ti(O-i-Pr)4. It is also used in greener amine synthesis by reductive amination as an alternative to borohydrides.

Notes

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage. Incompatible with strong oxidizing agents, amines and bases.

Références bibliographiques

Bhanu P. S. Chauhan.; Rajesh Sardar. Self-Assembled Stable Silver Nanoclusters and Nanonecklace Formation:? Poly(methylhydrosiloxane)-Mediated One-Pot Route to Organosols. Macromolecules. 2004, 37 (14), 5136-5139.

Bhanu P.S. Chauhan.; Philip Boudjouk. New neutral carrier-type ion sensors. Crown ether derivatives of poly(methylhydrosiloxane). Tetrahedron Letters. 1999, 40 (22), 4123-4126.

Convenient reducing agent with a wide variety of applications, for example:

Reduction of esters to alcohols, catalyzed by a combination of titanocene dichloride and either n-BuLi or EtMgBr: J. Org. Chem., 59, 4323 (1994). Alternatively, in combination with Ti(O-i-Pr)4 reduces a variety of esters, generally in high yield: J. Org. Chem., 60, 7884 (1995); Synlett, 831 (1994). For one-step reductive amination of carbonyl compounds in similar fashion, see: Synlett, 1655 (2000). Reduction of esters, carboxylic acids, ketones and aldehydes can also be accomplished conveniently with TBAF as a catalyst: Synlett, 989 (1997). For asymmetric reduction of ketones catalyzed by chiral quaternary fluorides, see: Tetrahedron Lett., 38, 5857 (1997).

Low-cost, safer alternative to Triethoxysilane, B22063, for reduction of phosphine oxides to phosphines, catalyzed by Ti(O-i-Pr)4. The products may be reacted in situ with alkyl halides to give a convenient one-pot conversion of phosphine oxides to phosphonium salts: Tetrahedron Lett., 35, 625 (1994).

Amine N-oxides can be reduced in the presence of Ti(O-i-Pr)4 or Pd(0): Synlett, 349 (2002).

Pd(0)-catalyzed hydrogenolysis of alkyl and aryl halides: J. Org. Chem., 51, 734 (1986). Pd(0)-catalyzed reductive cyclization of 1,6- and 1,7-enynes to give exomethylene cyclopentanes and cyclohexanes: J. Am. Chem. Soc., 109, 3161 (1987).

Low-cost alternative to Triethyl­silane, A10320, in a one-pot aromatic acylation-reduction technique allowing alkylation of the aromatic ring without the polysubstitution and rearrangements associated with Friedel-Crafts alkylations. Acylation in the presence of AlCl3 is followed by in situ reduction with PMHS: J. Chem. Soc., Perkin 1, 1705 (1989).

For a review of PMHS, see: J. Chem. Soc., Perkin 1, 3381 (1999).

Autres références

Code tarifaire harmonisé
2931.90
TSCA
Yes

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Analytique et matériel de laboratoire