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L14583 (S)-2-Methyl-CBS-oxazaborolidine, 1M soln. in toluene

Numéro de CAS
112022-81-8
Synonymes
(S)-3,3-Diphenyl-1-methylpyrrolidino[1,2-c]-1,3,2-oxazaborole

Stock No. Conditionnement Prix ($) Quantité Disponibilité
L14583-XF 1ml 36,90
L14583-AA 5ml 72,80
L14583-AC 25ml 230,00
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(S)-2-Methyl-CBS-oxazaborolidine, 1M soln. in toluene

MDL
MFCD00078439

Propriétés chimiques

Formule
C18H20BNO
Poids moleculaire
277.17
Point d'éclair
4°(39°F)
Densité
0.925
Storage & Sensitivity
Moisture Sensitive. Air Sensitive. Ambient temperatures.
Solubilité
Hydrolyzes in water.

Applications

(S)-2-Methyl-CBS-oxazaborolidine is used as an oxazaborolidine catalyst. It is also employed in the asymmetric reduction of prochiral ketones. Other applications include the enantioselective synthesis of α-hydroxy acids, α-amino acids, C2-symmetrical ferrocenyl diols and propargyl alcohols. It is an anhydrous catalyst for 'CBS' reduction reaction.

Notes

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage. Incompatible with oxidizing agents.

Références bibliographiques

Panayiotis A Procopiou.; Gillian E Morton.; Martin Todd.; Graham Webb. Enantioselective synthesis of (S)-salmeterol via asymmetric reduction of azidoketone by Pichia angusta. Tetrahedron: Asymmetry. 2001, 12 (14), 2005-2008.

Toshiyasu Takemoto.; Katsuyoshi Nakajima.; Yukiko Iio, Masakazu Tamura.; Takahide Nishi. Asymmetric synthesis of enantiomerically pure spiro[((2S)-hydroxy)indane-1,4?-piperidine]. Tetrahedron: Asymmetry. 1999, 10 (9), 1787-1793.

Anhydrous catalyst for 'CBS' reduction reaction. For examples of use in asymmetric reduction of ketones, see: Org. Synth. Coll., 9, 362, 676 (1998). For further information, see (S)-2-Methyl-CBS-oxazaborolidine monohydrate, L09219.

Mentions de danger et de prudence du SGH

Mentions de danger (UE): H225-H302-H333-H315-H361-H336-H373-H304

Highly flammable liquid and vapour. Harmful if swallowed. May be harmful if inhaled. Causes skin irritation. Suspected of damaging fertility or the unborn child. May cause drowsiness or dizziness. May cause damage to organs through prolonged or repeated exposure. May be fatal if swallowed and enters airways.

Mentions de prudence: P210-P260-P301+P310a-P303+P361+P353-P405-P501a

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Do not breathe dust/fume/gas/mist/vapours/spray. IF SWALLOWED: Immediately call a POISON CENTER/doctor IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Autres références

Classe de danger
3
Groupe d'emballage
II
Code tarifaire harmonisé
2934.99
TSCA
No

Recommandé

  • A10885

    Methanesulfonamide, 98+%
  • A10976

    Fumaric acid, 99%
  • A11410

    (Acetylmethylene)triphenylphosphorane, 99%
  • L14582

    (R)-2-Methyl-CBS-oxazaborolidine, 1M soln. in toluene
  • L15152

    Rhodium(II) acetate, dimer, 98+%

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Analytique et matériel de laboratoire