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112022-81-8 - (S)-2-Methyl-CBS-oxazaborolidine, 1M soln. in toluene - (S)-3,3-Diphenyl-1-methylpyrrolidino[1,2-c]-1,3,2-oxazaborole - L14583 - Alfa Aesar

L14583 (S)-2-Methyl-CBS-oxazaborolidine, 1M soln. in toluene

Numéro CAS
112022-81-8
Synonymes
(S)-3,3-Diphenyl-1-methylpyrrolidino[1,2-c]-1,3,2-oxazaborole

Dimensions Prix ($) Quantité Disponibilité
1ml 32,94
5ml 69,75
25ml 230,72
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(S)-2-Methyl-CBS-oxazaborolidine, 1M soln. in toluene

MDL
MFCD00078439

Propriétés chimiques

Formule
C18H20BNO
Poids formulaire
277.17
Point d'éclair
4°(39°F)
Densité
0.925
Sensibilité
Air & Moisture Sensitive
Solubilité
Hydrolyzes in water.

Applications

(S)-2-Methyl-CBS-oxazaborolidine is used as an oxazaborolidine catalyst. It is also employed in the asymmetric reduction of prochiral ketones. Other applications include the enantioselective synthesis of α-hydroxy acids, α-amino acids, C2-symmetrical ferrocenyl diols and propargyl alcohols. It is an anhydrous catalyst for 'CBS' reduction reaction.

Notes

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage. Incompatible with oxidizing agents.

Références bibliographiques

Panayiotis A Procopiou.; Gillian E Morton.; Martin Todd.; Graham Webb. Enantioselective synthesis of (S)-salmeterol via asymmetric reduction of azidoketone by Pichia angusta. Tetrahedron: Asymmetry. 2001, 12 (14), 2005-2008.

Toshiyasu Takemoto.; Katsuyoshi Nakajima.; Yukiko Iio, Masakazu Tamura.; Takahide Nishi. Asymmetric synthesis of enantiomerically pure spiro[((2S)-hydroxy)indane-1,4?-piperidine]. Tetrahedron: Asymmetry. 1999, 10 (9), 1787-1793.

Anhydrous catalyst for 'CBS' reduction reaction. For examples of use in asymmetric reduction of ketones, see: Org. Synth. Coll., 9, 362, 676 (1998). For further information, see (S)-2-Methyl-CBS-oxazaborolidine monohydrate, L09219.

Mentions de danger et de prudence du SGH

Mentions de danger (UE): H225-H304-H361-H373-H315-H336

Highly flammable liquid and vapour. May be fatal if swallowed and enters airways. Suspected of damaging fertility or the unborn child. May cause damage to organs through prolonged or repeated exposure. Causes skin irritation. May cause drowsiness or dizziness.

Mentions de prudence: P210-P260-P201-P261-P280-P281-P301+P310-P303+P361+P353-P405-P501a

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Do not breathe dust/fume/gas/mist/vapours/spray. Obtain special instructions before use. Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. Use personal protective equipment as required. IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Autres références

Classe de danger
3
Groupe d'emballage
II
Code tarifaire harmonisé
2934.99
TSCA
No

Recommandé

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    (R)-2-Methyl-CBS-oxazaborolidine, 1M soln. in toluene
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    Rhodium(II) acetate, dimer, 98+%

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