Consentement d'utilisation des Cookies

J'accepte Notre site sauvegarde des traceurs textes (cookies) sur votre appareil afin de vous garantir de meilleurs contenus et à des fins de collectes statistiques.Vous pouvez désactiver l'usage des cookies en changeant les paramètres de votre navigateur. En poursuivant votre navigation sur notre site sans changer vos paramètres de navigateur vous nous accordez la permission de conserver des informations sur votre appareil.

40949-94-8 - Potassium bis(trimethylsilyl)amide, 15% w/w in toluene - KHMDS - Potassium hexamethyldisilazide - L15022 - Alfa Aesar

L15022 Potassium bis(trimethylsilyl)amide, 15% w/w in toluene

Numéro CAS
40949-94-8
Synonymes
KHMDS
Potassium hexamethyldisilazide

Cet article ne peut pas être commandé en ce moment. Veuillez réessayer plus tard.

Ajouter au devis en vrac

Potassium bis(trimethylsilyl)amide, 15% w/w in toluene

MDL
MFCD00010330
EINECS
424-100-2

Propriétés chimiques

Formule
C6H18KNSi2
Poids formulaire
199.49
Point d'éclair
7°(44°F)
Densité
0.881
Indice de réfraction
1.4900
Sensibilité
Air & Moisture Sensitive
Solubilité
Reacts with water.

Applications

Potassium bis(trimethylsilyl)amide is used in the generation of K enolates. It is also used in the Wittig reaction, to give Li salt-free product distribution for selective (Z)-alkene formation and used with 18-crown-6 for selective formation of (Z)-?ß-unsaturated esters from phosphonates.

Notes

It is sensitive to moisture and air. Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage. Handle and store under inert gas. Incompatible with strong oxidizing agents.

Références bibliographiques

Kris F. Tesh.; Timothy P. Hanusa.; John C. Huffman. Ion pairing in [bis(trimethylsilyl)amido]potassium: The x-ray crystal structure of unsolvated [KN(SiMe3)2]2. Inorg. Chem. 1990, 29 (8), 1584-1586 .

Jörg Brüning. Lithium and potassium bis(trimethylsilyl)amide: Utilizing non-nucleophilic bases as nitrogen sources. Tetrahedron Letters. 1997, 38 (18), 3187-3188.

Sterically hindered strong base, compare Sodium bis(trimethyl­silyl)­amide, L13352 and Lithium bis(trimethyl­silyl)­amide, L15012. Used in the generation of K enolates, preferred to their Li or Na counterparts in some reactions, see e.g.: Tetrahedron Lett., 32, 1779 (1991); J. Am. Chem. Soc., 109, 6881 (1987); 111, 1063 (1989).

Also used in the Wittig reaction, to give Li salt-free product distribution for selective (Z)-alkene formation: J. Org. Chem., 45, 4260 (1980). Has also been used with 18-crown-6 for selective formation of (Z)-ɑß-unsaturated esters from phosphonates: Tetrahedron Lett., 24, 4405 (1983).

Mentions de danger et de prudence du SGH

Mentions de danger (UE): H225-H304-H361-H373-H314-H336

Highly flammable liquid and vapour. May be fatal if swallowed and enters airways. Suspected of damaging fertility or the unborn child. May cause damage to organs through prolonged or repeated exposure. Causes severe skin burns and eye damage. May cause drowsiness or dizziness.

Mentions de prudence: P210-P260-P201-P261-P301+P310-P303+P361+P353-P305+P351+P338-P301+P330+P331-P405-P501a

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Do not breathe dust/fume/gas/mist/vapours/spray. Obtain special instructions before use. Avoid breathing dust/fume/gas/mist/vapours/spray. IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Rinse mouth. Do NOT induce vomiting. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Autres références

Beilstein
4006754
Classe de danger
3
Groupe d'emballage
II
Code tarifaire harmonisé
2931.90
TSCA
No

Recommandé

Consulté récemment

Produits chimiques

Sciences de la vie

Métaux et matériaux

Catalyseurs

Analytique et matériel de laboratoire