Diethylenetriaminepentaacetic acid dianhydride is a reagent used for introducing a strong chelator. It is employed in the synthesis of macrocyclic ligands and lanthanide complexes that are useful as MRI enhancers.
V.-M. Mukkala.; H. Mikola.; I. Hemmilä. The synthesis and use of activated N-benzyl derivatives of diethylenetriaminetetraacetic acids: Alternative reagents for labeling of antibodies with metal ions. Analytical Biochemistry. 1989, 176 (2), 319-325.
David L. Ladd.; Robert Hollister.; Xin Peng.; Donna Wei.; Gang Wu.; Daniel Delecki.; Robert A. Snow.; John L. Toner.; Kenneth Kellar.; Jennifer Eck.; Vinay C. Desai.; Gemma Raymond.; Lewis B. Kinter.; Terry S. Desser M. D. ; Daniel L. Rubin M. D. Polymeric Gadolinium Chelate Magnetic Resonance Imaging Contrast Agents:? Design, Synthesis, and Properties. Bioconjugate Chem. 1999, 10 (3), 361-370.
Mentions de danger (UE): H315-H319-H335
Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Mentions de prudence: P261-P280a-P305+P351+P338-P304+P340-P405-P501a
Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.