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999-97-3 - Hexamethyldisilazane, Electronic grade, 99+% - Bis(trimethylsilyl)amine - HMDS - L16519 - Alfa Aesar

L16519 Hexamethyldisilazane, Electronic grade, 99+%

Numéro CAS
999-97-3
Synonymes
Bis(trimethylsilyl)amine
HMDS

Dimensions Prix ($) Quantité Disponibilité
25ml 22,77
100ml 55,98
500ml 162,90
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Hexamethyldisilazane, Electronic grade, 99+%

MDL
MFCD00008259
EINECS
213-668-5

Propriétés chimiques

Formule
C6H19NSi2
Poids formulaire
161.40
Point de fusion
-78°
Point d'ébullition
126°
Point d'éclair
8°(46°F)
Densité
0.774
Indice de réfraction
1.4080
Sensibilité
Moisture Sensitive
Solubilité
Miscible with methanol, ethyl ether, chloroform and benzene. Immiscible with water.

Applications

Hexamethyldisilazane is used as a solvent in organic synthesis and organometallic chemistry. It is often used as an adhesion promoter for photoresist in photolithography. Further, it is used for the preparation of trimethylsilyl ethers from hydroxy compounds. It is used as an alternative to critical point drying during sample preparation in electron microscopy. It is added to analyte to get silylated diagnostic products during pyrolysis in gas chromatography- mass spectrometry.

Notes

Incompatible with strong oxidizing agents and strong acids.  

Références bibliographiques

Convenient, mild silylating reagent which generates gaseous ammonia as the only by-product (see Appendix 4). Non-acidic substrates normally require a catalyst.

Silylation of alcohols, including carbohydrates, is catalyzed by TMS chloride: J. Org. Chem., 23, 50 (1958); J. Am. Chem. Soc., 85, 2497 (1963); Chem. Ind. (London), 794 (1984). Silylation of phenols occurs readily, see also: Liebigs Ann. Chem., 20 (1973).

HMDS in the presence of TMS chloride permits the selective O-silylation of amino alcohols: Synthesis, 990 (1988). Alcohols and phenols can be silylated in the presence of amines and thiols with ZnCl2 as catalyst: Synth. Commun., 23, 1633 (1993).

For conversion of carbonyl groups to silyl enol ethers, see Iodotrimethyl­silane, A12902.

A range of catalysts for silylation with HMDS, including saccharin and sodium saccharin, has been recommended: J. Org. Chem., 47, 3966 (1982), for silylation of alcohols, phenols, thiols, carboxylic acids, amides, thioamides, hydroxamic acids, hydrazides, NH-groups of heterocycles, hydrazines, 1,3-diketones, etc. The use of TBAF (0.02 eq.) or iodine (0.01 eq.) also provide mild procedures for O-silylation: Tetrahedron Lett., 35, 8409 (1994); J. Org. Chem., 65, 7228 (2000).

Can also function as a protected form of ammonia, e.g. to convert acid chlorides to primary amides: Synthesis, 517 (1985), and substituted maleic anhydrides to maleimides: Tetrahedron Lett., 31, 5201 (1990).

In combination with DMSO, thiols are oxidized to disulfides under nearly neutral conditions: Synlett, 346 (2002).

The Na, Li and K derivatives are useful strong bases; see Sodium bis(trimethyl­silyl)­amide, L13352, Lithium bis(trimethyl­silyl)­amide, L15012, and Potassium bis(trimethyl­silyl)­amide, L15022.

Demin, V. N.; Smirnova, T. P.; Borisov, V. O.; Grachev, G. N.; Smirnov, A. L.; Khomyakov, M. N. Physical-chemical properties of silicon carbonitride films prepared using laser-plasma deposition from hexamethyldisilazane. Glass Phys. Chem. 2015, 41 (2), 232-236.

Molnár, B.; Csámpai, A.; Molnár-Perl, I. Hexamethyldisilazane as an Acylation Generator for Perfluorocarboxylic Acids in Quantitative Derivatization of Primary Phenylalkyl Amines Confirmed by GC/MS and Computations. Anal. Chem. 2014, 87 (2), 848-852.

Mentions de danger et de prudence du SGH

Mentions de danger (UE): H225-H311-H331-H302-H314-H318

Highly flammable liquid and vapour. Toxic in contact with skin. Toxic if inhaled. Harmful if swallowed. Causes severe skin burns and eye damage. Causes serious eye damage.

Mentions de prudence: P210-P260-P261-P280-P303+P361+P353-P305+P351+P338-P361-P301+P330+P331-P405-P501a

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Do not breathe dust/fume/gas/mist/vapours/spray. Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Autres références

Merck
14,4689
Beilstein
635752
Classe de danger
3
Groupe d'emballage
II
Code tarifaire harmonisé
2931.90
TSCA
Yes
RTECS
JM9230000

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Analytique et matériel de laboratoire