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65094-22-6 - Diethyl (bromodifluoromethyl)phosphonate, 97% - Bromodifluoromethyl diethyl phosphonate - Diethyl bromodifluoromethanephosphonate - L16715 - Alfa Aesar

L16715 Diethyl (bromodifluoromethyl)phosphonate, 97%

Numéro de CAS
65094-22-6
Synonymes
Bromodifluoromethyl diethyl phosphonate
Diethyl bromodifluoromethanephosphonate

Conditionnement Prix ($) Quantité Disponibilité
1g 22,70
5g 65,90
25g 251,00
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Diethyl (bromodifluoromethyl)phosphonate, 97%

MDL
MFCD00069118

Propriétés chimiques

Formule
C5H10BrF2O3P
Poids moleculaire
267.01
Point d'ébullition
99-102°/16mm
Point d'éclair
>110°(230°F)
Densité
1.503
Indice de réfraction
1.4160
Solubilité
Not miscible or difficult to mix in water.

Applications

Diethyl (bromodifluoromethyl)phosphonate is used as a reactant for the preparation of phosphopeptide mimetic prodrugs targeted to Src homology 2 (SH2) domain of signal transducer and activator of transcription 3 (Stat3), synthesis of Mycobacterium tuberculosis protein tyrosine phosphatase inhibitory difluoromethylphosphonic acid derivatives via multi step synthesis with Suzuki coupling and resolution as key steps and P-C bond cleavage on basic hydrolysis.

Notes

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage. Incompatible with oxidizing agents.

Références bibliographiques

Pijus K Mandal.; Fengqin Gao.; Zhen Lu.; Zhiyong Ren.; Rajagopal Ramesh.; J Sanderson Birtwistle.; Kumaralal K Kaluarachchi.; Xiaomin Chen.; Robert C Bast.; Warren S Liao.; John S McMurray. Potent and selective phosphopeptide mimetic prodrugs targeted to the Src homology 2 (SH2) domain of signal transducer and activator of transcription 3. Journal of medicinal and pharmaceutical chemistry. 2011, 54 (10), 3549-3563.

Katherine A Rawls.; Christoph Grundner.; Jonathan A Ellman. Design and synthesis of nonpeptidic, small molecule inhibitors for the Mycobacterium tuberculosis protein tyrosine phosphatase PtpB. Organic & Biomolecular Chemistry. 2010, 8 (18), 4066-4070.

Mentions de danger et de prudence du SGH

Mentions de danger (UE): H315-H319

Causes skin irritation. Causes serious eye irritation.

Mentions de prudence: P280a-P264-P305+P351+P338-P321-P332+P313-P337+P313

Wear protective gloves and eye/face protection. Wash thoroughly after handling. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Specific treatment (see label). If skin irritation occurs: Get medical advice/attention. If eye irritation persists:

Autres références

Beilstein
1944045
Code tarifaire harmonisé
2931.39
TSCA
No

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Catalyseurs

Analytique et matériel de laboratoire