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27784-76-5 - tert-Butyl diethylphosphonoacetate, 95% - Diethylphosphonoacetic acid tert butyl ester - L17651 - Alfa Aesar

L17651 tert-Butyl diethylphosphonoacetate, 95%

Numéro CAS
27784-76-5
Synonymes
Diethylphosphonoacetic acid tert butyl ester

Dimensions Prix ($) Quantité Disponibilité
1g 26,82
5g 81,54
25g 299,87
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tert-Butyl diethylphosphonoacetate, 95%

MDL
MFCD00075414
EINECS
000-000-0

Propriétés chimiques

Formule
C10H21O5P
Poids formulaire
252.25
Point d'ébullition
100-103°/1.5mm
Point d'éclair
>110°(230°F)
Densité
1.074
Indice de réfraction
1.4310
Solubilité
Not miscible or difficult to mix in water.

Applications

tert-Butyl diethylphosphonoacetate is used as a reactant for preparation of hydroxymethylated dihydroxyvitamin D3 analogs via Wittig-Horner approach, as potential antitumor agents, synthesis of phosphopeptide mimetic prodrugs targeted to Src homology 2 (SH2) domain of signal transducer and activator of transcription 3 (Stat 3) and bicyclic triaminophosphine-promoted stereoselective synthesis of a,ß-unsaturated esters, fluorides, and nitriles from aldehydes and ketones using Wadsworth-Emmons phosphonates

Notes

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage. Incompatible with oxidizing agents.

Références bibliographiques

Pijus K Mandal.; Fengqin Gao.; Zhen Lu.; Zhiyong Ren.; Rajagopal Ramesh.; J Sanderson Birtwistle.; Kumaralal K Kaluarachchi.; Xiaomin Chen.; Robert C Bast.; Warren S Liao.; John S McMurray. Potent and selective phosphopeptide mimetic prodrugs targeted to the Src homology 2 (SH2) domain of signal transducer and activator of transcription 3 . Journal of medicinal and pharmaceutical chemistry. 2011, 54 (10), 3549-3563.

Maria A Regueira.; Shaonly Samanta.; Peter J Malloy.; Paloma Ordonez-Moran.; Diana Resende.; Fredy Sussman.; Alberto Munoz.; Antonio Mourino.; David Feldman.; Mercedes Torneiro. Synthesis and biological evaluation of 1α,25-dihydroxyvitamin D(3) analogues hydroxymethylated at C-26. Langmuir. 2011, 54 (11), 3950-3962.

Mentions de danger et de prudence du SGH

Mentions de danger (UE): H315-H319

Causes skin irritation. Causes serious eye irritation.

Mentions de prudence: P280-P264-P305+P351+P338-P362-P321-P332+P313-P337+P313-P302+P352

Wear protective gloves/protective clothing/eye protection/face protection. Wash thoroughly after handling. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Take off contaminated clothing and wash before reuse. Specific treatment (see label). If skin irritation occurs: Get medical advice/attention. If eye irritation persists: IF ON SKIN: Wash with plenty of soap and water.

Autres références

Beilstein
2050126
Code tarifaire harmonisé
2931.90
TSCA
No

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