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68957-94-8 - 1-Propylphosphonic acid cyclic anhydride, 50+% soln. in DMF - 1-Propanephosphonic acid cyclic anhydride - T3P - L19271 - Alfa Aesar

L19271 1-Propylphosphonic acid cyclic anhydride, 50+% soln. in DMF

Numéro CAS
68957-94-8
Synonymes
1-Propanephosphonic acid cyclic anhydride
T3P

Dimensions Prix ($) Quantité Disponibilité
10g 36,46
50g 151,41
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1-Propylphosphonic acid cyclic anhydride, 50+% soln. in DMF

MDL
MFCD00006583
EINECS
422-210-5

Propriétés chimiques

Formule
C9H21O6P3
Poids formulaire
318.19
Point d'ébullition
153°
Point d'éclair
62°(143°F)
Densité
1.090
Indice de réfraction
1.4505
Sensibilité
Moisture Sensitive
Solubilité
Miscible with dichloromethane, dioxane, terahydrofuran, polar and aprotic organic solvents.

Applications

1-Propylphosphonic acid cyclic anhydride is used in the synthesis of N-acyloxythiazole-2(3H)-thiones. It is also used to promote the synthesis of hydroxamic acids from carboxylic acids. Further, it is employed as an efficient promoter for the Lossen rearrangement to synthesis urea and carbamate derivatives.

Notes

Moisture sensitive. Incompatible withstrong oxidizing agents.

Références bibliographiques

T3P is a registered trademark of Archimica.

For use in the synthesis of N-acyloxythiazole-2(3H)-thiones, see: Synlett, 371 (2000).

Augustine, J. K.; Kumar, R.; Bombrun, A.; Mandal, A. B. An efficient catalytic method for the Beckmann rearrangement of ketoximes to amides and aldoximes to nitriles mediated by propylphosphonic anhydride (T3P®). Tetrahedron Lett. 2011, 52 (10), 1074-1077.

Augustine, J. K.; Bombrun, A.; Ramappa, B.; Boodappa, C. An efficient one-pot synthesis of coumarins mediated by propylphosphonic anhydride (T3P) via the Perkin condensation. Tetrahedron Lett. 2012, 53 (33), 4422-4425.

Mentions de danger et de prudence du SGH

Mentions de danger (UE): H360-H314-H302-H332-H227

May damage fertility or the unborn child. Causes severe skin burns and eye damage. Harmful if swallowed. Harmful if inhaled. Combustible liquid.

Mentions de prudence: P210-P260-P201-P261-P280-P303+P361+P353-P305+P351+P338-P301+P330+P331-P405-P501a

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Do not breathe dust/fume/gas/mist/vapours/spray. Obtain special instructions before use. Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Autres références

Beilstein
5079255
Classe de danger
8
Groupe d'emballage
II
Code tarifaire harmonisé
2934.99
TSCA
No

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Catalyseurs

Analytique et matériel de laboratoire