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67-51-6 - 3,5-Dimethyl-1H-pyrazole, 99% - A10157 - Alfa Aesar

A10157 3,5-Dimethyl-1H-pyrazole, 99%

Codice CAS
67-51-6
Sinonimi

Dimensioni Prezzo ($) Quantità Disponibilità
50g 29,60
250g 119,00
1000g 264,00
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3,5-Dimethyl-1H-pyrazole, 99%

MDL
MFCD00005243
EINECS
200-657-5

Proprietà chimiche

Formula
C5H8N2
Peso formula
96.13
Punto di fusione
105-108°
Punto di ebollizione
218°
Solubilità
Soluble in water, methanol 0.1 g/mL.

Applicazioni

3,5-Dimethyl-1H-pyrazole is combined with Chromium(VI)­ oxide, is a valuable reagent for oxidation of primary and secondary alcohols to carbonyl compounds. It reacts with malonic esters gives a family of cross-conjugated monomeric betaines. It is a common reagent for the preparation of pyrazolato ligated complexes. It is also used to prepare N-1-substituted derivatives having antibacterial activity.

Note

Store away from oxidizing agents. Store in a cool, dry condition in well sealed containers.

Letteratura

Hasnae Bendaha; Lisa Yu; Rachid Touzani; Rachid Souane; Guri Giaever; Corey Nislow; Charles Boone; Sghir El Kadiri; Grant W. Brown; Mohammed Bellaoui. New azole antifungal agents with novel modes of action: Synthesis and biological studies of new tridentate ligands based on pyrazole and triazole. European Journal of Medicinal Chemistry. 2011, 46 (9), 4117-4124.

F Castro González; A Martínez Garza. Comparative study of analgesics. Practica odontologica. 1986, 7 (2), 30-34.

The combination with Chromium(VI)­ oxide, 12522 is a valuable reagent for oxidation of primary and secondary alcohols to carbonyl compounds in very high yields: Tetrahedron Lett., 4499 (1973). With Pyridinium chlorochromate, A11752, allylic alcohols are oxidized selectively in the presence of secondary alcohols: J. Org. Chem., 48, 4766 (1983).

Reaction of pyrazoles with malonic esters gives a family of cross-conjugated monomeric betaines: Synthesis, 629 (1989):

Rischio GHS e dichiarazioni precauzionali

Dichiarazioni di rischio (UE): H302-H315-H319-H335

Harmful if swallowed. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Dichiarazioni precauzionali: P261-P280a-P305+P351+P338-P304+P340-P405-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Altri riferimenti

Beilstein
106325
Codice tariffe armonizzato
2933.19
TSCA
Yes
RTECS
UQ6477600

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