Autorizzo l’utilizzo di cookies.

Accetto Utilizziamo cookies per migliorare il nostro servizio e realizzare statistiche. Questa funzione puó essere disattivata cambiando la configurazione del browser. Continuando a navigare senza modificare questi parametri, consideriamo che l’uso di cookies sia accettato

6066-82-6 - N-Hydroxysuccinimide, 98+% - HOSu - 1-Hydroxy-2,5-pyrrolidinedione - A10312 - Alfa Aesar

A10312 N-Hydroxysuccinimide, 98+%

Codice CAS
6066-82-6
Sinonimi
HOSu
1-Hydroxy-2,5-pyrrolidinedione

Dimensioni Prezzo ($) Quantità Disponibilità
25g 33,80
100g 90,70
500g 362,00
Aggiungi al carrello Aggiungi al preventivo generale Visualizza articolo

N-Hydroxysuccinimide, 98+%

MDL
MFCD00005516
EINECS
228-001-3

Proprietà chimiche

Formula
C4H5NO3
Peso formula
115.09
Punto di fusione
94-99°
Sensibilità
Hygroscopic
Solubilità
Soluble in water, dimethyl formamide, alcohols and ethyl acetate. Insoluble in cold ether.

Applicazioni

N-Hydroxysuccinimide is used for improved amidations in the carbodiimide method. It is also used to activate a carboxyl group and reacts with amine to form amide. It is involved in the preparation of N-hydroxymaleimide-styrene copolymer. Further, it finds use in analytical chemistry. As an additive, it is used in the carbodiimide method for improved amidations and peptide couplings.

Note

Hygroscopic. Moisture sensitive. Incompatible with strong oxidizing agents, acid chlorides, acid anhydrides and strong bases. Store in a cool place.

Letteratura

Reagent for the preparation of active N-hydroxysuccinimide esters for peptide coupling with minimum racemization: J. Am. Chem. Soc., 86, 1839 (1964), or as an additive in the DCC method (see N,N'-Dicyclohexyl­carbodiimide, A10973 ) to suppress racemization: J. Am. Chem. Soc., 89, 7151 (1967). For peptide reagents, see Appendix 6.

For a study of the aminolysis of N-hydroxysuccinimide esters, see: J. Org. Chem., 53, 3583 (1988).

Park, C.; Vo, C. L. N.; Kang, T.; Oh, E.; Lee, B. J. New method and characterization of self-assembled gelatin-oleic nanoparticles using a desolvation method via carbodiimide/N-hydroxysuccinimide (EDC/NHS) reaction. Eur. J. Pharm. Biopharm. 2015, 89, 365-373.

Peng, Z.; McGee, W. M.; Bu, J.; Barefoot, N. Z.; McLuckey, S. A. Gas phase reactivity of carboxylates with N-hydroxysuccinimide esters. J. Am. Soc. Mass. Spectrom. 2015, 26 (1), 174-180.

Rischio GHS e dichiarazioni precauzionali

Dichiarazioni precauzionali: P260-P201-P280-P304+P340-P405-P501a

Do not breathe dust/fume/gas/mist/vapours/spray. Obtain special instructions before use. Wear protective gloves/protective clothing/eye protection/face protection. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Altri riferimenti

Beilstein
113913
Codice tariffe armonizzato
2925.19
TSCA
Yes

Raccomandato

  • A10807

    1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride, 98+%
  • A10973

    N,N'-Dicyclohexylcarbodiimide, 99%
  • A12646

    Triethylamine, 99%
  • A13016

    4-(Dimethylamino)pyridine, 99%
  • 43998

    Dimethyl sulfoxide, anhydrous, 99.8+%, packaged under Argon in resealable ChemSeal™ bottles

Visualizzati di recente

Prodotti chimici

Scienze della vita

Metalli e materiali

Catalizzatori

Apparecchiature di analisi e di laboratorio