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5390-04-5 - 4-Pentyn-1-ol, 97% - 1-Pentyne-5-ol - 4-Pentynyl alcohol - A10405 - Alfa Aesar

A10405 4-Pentyn-1-ol, 97%

Codice CAS
5390-04-5
Sinonimi
1-Pentyne-5-ol
4-Pentynyl alcohol

Dimensioni Prezzo ($) Quantità Disponibilità
5g 38,10
25g 148,00
100g 517,00
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4-Pentyn-1-ol, 97%

MDL
MFCD00002974
EINECS
226-383-6

Proprietà chimiche

Formula
C5H8O
Peso formula
84.12
Punto di ebollizione
153-155°
Punto di infiammabilità
62°(143°F)
Densità
0.907
Indice di rifrazione
1.4450
Solubilità
Miscible with water.

Applicazioni

4-Pentyn-1-ol is widely utilized in ring-opening polymerization reactions. It plays an important role as a starting reagent in stereo selective total synthesis of antimicrobial marine metabolites, ieodomycin A and B. It is also used in the preparation of 3-pent-4-ynyloxy phthalonitrile.

Note

Keep away from sources of ignition. Keep the container tightly closed in a dry and well-ventilated place.

Letteratura

Readily forms a dilithio-derivative, allowing regioselective C-alkylation in the 5-position without the need for protection of the alcohol function. Thus, alkylation with the THP ether of 5-bromopentanol gives a 10-carbon chain as part of the synthesis of a macrolide pheromone, and in other natural product syntheses: J. Org. Chem., 58, 7535 (1993), and references therein.

/n

Fjermestad, T.; Ho, J. H. H.; Macgregor, S. A.; Messerle, B. A.; Tuna, D. Computational Study of the Mechanism of Cyclic Acetal Formation via the Iridium(I)-Catalyzed Double Hydroalkoxylation of 4-Pentyn-1-ol with Methanol. Organometallics 2011, 30 (3), 618-626.

Møllendal, H.; Dreizler, H.; Sutter, D. H. Structural and Conformational Properties of 4-Pentyn-1-ol As Studied by Microwave Spectroscopy and Quantum Chemical Calculations. J. Phys. Chem. A 2007, 111 (46), 11801-11808.

Rischio GHS e dichiarazioni precauzionali

Dichiarazioni di rischio (UE): H227-H315-H319-H335

Combustible liquid. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Dichiarazioni precauzionali: P260u-P201-P280-P303+P361+P353-P305+P351+P338-P301+P330+P331-P304+P340-P310a-P405-P501a

Obtain special instructions before use. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Altri riferimenti

Beilstein
1736712
Codice tariffe armonizzato
2905.29
TSCA
No

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