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55-21-0 - Benzamide, 98+% - A10501 - Alfa Aesar

A10501 Benzamide, 98+%

Codice CAS
55-21-0
Sinonimi

Dimensioni Prezzo ($) Quantità Disponibilità
100g 26,20
500g 70,10
2500g 268,00
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Benzamide, 98+%

MDL
MFCD00007968
EINECS
200-227-7

Proprietà chimiche

Formula
C7H7NO
Peso formula
121.14
Punto di fusione
125-129°
Punto di ebollizione
288°
Punto di infiammabilità
180°(356°F)
Densità
1.341
Solubilità
Soluble in water, methanol, ammonia, pyridine, carbon tetrachloride, carbon disulfide and ethanol. Slightly soluble in benzene and ethyl ether.

Applicazioni

Benzamide is utilized to study the mechanism of photocatalytic decomposition of aqueous solution of acetic acid, acetamide and acetonitrile in the presence of semiconductors. It is used as a nictoinamide-mimic PARP inhibitor and neuroprotectant. Further, it is used to develop a robust screening method to study biotransformations using (+)-gamma-lactamase enzyme. It is also employed in the determination of glycine. In addition to this, it is used as an intermediate in organic synthesis as well as in the production of pharmaceuticals and dyes.

Note

Incompatible with strong oxidizing agents and strong bases.

Letteratura

Reduction with lithium aluminum hydride gives benzylamine. By using lithium tris(diethylamino)aluminum hydride (see Diethyl­amine, A11716), selective reduction to benzaldehyde is possible: Tetrahedron Lett., 32, 6903 (1991).

An exceptionally mild method for dehydration of amides to nitriles by transamidation with acetonitrile in the presence of an aldehyde and formic acid is exemplified by the high yield conversion of benzamide to benzonitrile: J. Org. Chem., 61, 6486 (1996).

Barrett, K. T.; Miller, S. J. Regioselective Derivatizations of a Tribrominated Atropisomeric Benzamide Scaffold. Org. Lett. 2015, 17 (3), 580-583.

Manna, S.; Antonchick, A. P. Organocatalytic Oxidative Annulation of Benzamide Derivatives with Alkynes. Angew. Chem. Int. Ed. 2014, 53 (28), 7324-7327.

Rischio GHS e dichiarazioni precauzionali

Dichiarazioni di rischio (UE): H302-H341

Harmful if swallowed. Suspected of causing genetic defects.

Dichiarazioni precauzionali: P201-P280-P301+P312a-P308+P313-P405-P501a

Obtain special instructions before use. Wear protective gloves/protective clothing/eye protection/face protection. IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. IF exposed or concerned: Get medical advice/attention. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Altri riferimenti

Merck
14,1060
Beilstein
385876
Codice tariffe armonizzato
2924.29
TSCA
Yes
RTECS
CU8700000

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