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14470-28-1 - 4-Methoxytrityl chloride, 97% - p-Anisylchlorodiphenylmethane - 4-Methoxytriphenylmethyl chloride - A10545 - Alfa Aesar

A10545 4-Methoxytrityl chloride, 97%

Codice CAS
14470-28-1
Sinonimi
p-Anisylchlorodiphenylmethane
4-Methoxytriphenylmethyl chloride

Dimensioni Prezzo ($) Quantità Disponibilità
10g 35,10
50g 124,00
250g 546,00
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4-Methoxytrityl chloride, 97%

MDL
MFCD00000814
EINECS
238-463-8

Proprietà chimiche

Formula
C20H17ClO
Peso formula
308.81
Punto di fusione
121-125°
Sensibilità
Moisture Sensitive
Solubilità
Soluble in toluene.

Applicazioni

It is used as selective protecting reagent that is used for primary hydroxyl groups.

Note

It is hygroscopic. Incompatible with oxidizing agents.

Letteratura

Reagent for protection of alcohols, cf Chlorotriphenyl­methane, A11799, as their monomethoxytrityl (Mmt) ethers, intermediate in acid-lability between trityl (Trt) and dimethoxytrityl (Dmt); see 4,4'-Dimethoxytrityl­ chloride, A11626. For use of DMAP as a catalyst for methoxytritylation of alcohols and amines, see: Tetrahedron Lett., 21, 3899 (1980); J. Org. Chem., 47, 571 (1982); Chem. Lett., 15 (1982).

In a comparison with Dmt for N-protection during solid-phase peptide synthesis, the N-Mmt group was found to survive intact whereas N-Dmt derivatives decomposed slowly in protic solvents: Tetrahedron. Lett., 39, 1733 (1998).

Rischio GHS e dichiarazioni precauzionali

Dichiarazioni di rischio (UE): H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Dichiarazioni precauzionali: P261-P280a-P305+P351+P338-P304+P340-P405-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Altri riferimenti

Beilstein
798425
Codice tariffe armonizzato
2909.30
TSCA
No

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