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88-67-5 - 2-Iodobenzoic acid, 98+% - A10563 - Alfa Aesar

A10563 2-Iodobenzoic acid, 98+%

Codice CAS
88-67-5
Sinonimi

Dimensioni Prezzo ($) Quantità Disponibilità
25g 19,60
100g 57,60
500g 252,00
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2-Iodobenzoic acid, 98+%

MDL
MFCD00002419
EINECS
201-850-7

Proprietà chimiche

Formula
C7H5IO2
Peso formula
248.02
Punto di fusione
160-164°
Densità
2.250
Sensibilità
Light Sensitive
Solubilità
Soluble in dimethyl sulfoxide and methanol

Applicazioni

Reagent for detection of sulfhydryl groups in proteins2-Iodobenzoic acid acts as a precursor in the preparation of 2-Iodoxybenzoic acid (IBX) and Dess-Martin periodinane, which finds application as an oxidizing agent in synthetic chemistry. It is also used in Suzuki reaction.

Note

Incompatible with oxidizing agents.

Letteratura

Can be used to protect alcohols as their 2-iodobenzoates by DCC coupling. The group is removed by oxidation with chlorine under basic conditions: Tetrahedron Lett., 28, 5005 (1987).

In the presence of Tetrakis(triphenyl­phosphine)­palladium(0)­, 10548 , and zinc chloride, undergoes cyclization with terminal acetylenes to give isocoumarins: J. Org. Chem., 60, 3711 (1995):

For related reactions, see 4,4-Dimethyl-2-pentyne, L10210 , 2-Iodoaniline, A13059 and 2-Iodophenol, A13599 .

Dang, Y.; Qu, S.; Nelson, J. W.; Pham, H. D.; Wang, Z. X.; Wang, X. The Mechanism of a Ligand-Promoted C(sp3)-H Activation and Arylation Reaction via Palladium Catalysis: Theoretical Demonstration of a Pd(II)/Pd(IV) Redox Manifold. J. Am. Chem. Soc. 2015, 137 (5), 2006-2014.

Yoshimura, A.; Nguyen, K. C.; Klasen, S. C.; Saito, A.; Nemykin, V. N.; Zhdankin, V. V. Preparation, structure, and versatile reactivity of pseudocyclic benziodoxole triflate, new hypervalent iodine reagent. Chem. Commun. 2015, 51 (37), 7835-7838.

Rischio GHS e dichiarazioni precauzionali

Dichiarazioni di rischio (UE): H302-H315-H319-H335

Harmful if swallowed. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Dichiarazioni precauzionali: P260-P201-P280g-P304+P340-P405-P501a

Do not breathe dust/fume/gas/mist/vapours/spray. Obtain special instructions before use. Wear protective gloves. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Altri riferimenti

Merck
14,5030
Beilstein
1861406
Codice tariffe armonizzato
2916.39
TSCA
Yes
RTECS
DH2975000

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