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6148-64-7 - Ethyl potassium malonate, 98% - Malonic acid monoethyl ester potassium salt - Monoethyl malonate potassium salt - A10720 - Alfa Aesar

A10720 Ethyl potassium malonate, 98%

Codice CAS
6148-64-7
Sinonimi
Malonic acid monoethyl ester potassium salt
Monoethyl malonate potassium salt

Dimensioni Prezzo ($) Quantità Disponibilità
25g 47,88
100g 134,40
500g 584,80
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Ethyl potassium malonate, 98%

MDL
MFCD00035603
EINECS
228-156-7

Proprietà chimiche

Formula
C5H7KO4
Peso formula
170.21
Punto di fusione
ca 200° dec.
Sensibilità
Hygroscopic
Solubilità
Soluble in water.

Applicazioni

Ethyl potassium malonate is used as a competitive inhibitor of the enzyme succinate dehydrogenase. It acts as a precursor to produce (trimethylsilyl)ethyl malonate, which is utilized to prepare beta-ketoesters by acylation. Further, it reacts with aryl nitriles to prepare beta-amino acrylates in the presence of zinc chloride and a catalytic amount of Hünig's base. In addition to this, it serves as an intermediate for the preparation of ethyl tert-butyl malonate.

Note

Hygroscopic. Incompatible with strong oxidizing agents.

Letteratura

An improved method for acylation with acid chlorides utilizes the Rathke MgCl2-triethylamine reagent in acetonitrile or ethyl acetate to give ß-keto esters in very high yields: Synthesis, 290 (1993):

Compare Diethyl­ malonate, A15468 and Dimethyl­ malonate, A11007, for other applications of this technique. See also Ethyl­ hydrogen malonate, A12627.

Alternatively, ß-keto esters can be obtained in high yield by reaction with TMS chloride to generate ethyl trimethylsilyl malonate, followed by in situ reaction with acyl imidazoles or acyl chlorides in the presence of DBU: Tetrahedron Lett., 35, 9323 (1994).

Tancock, J.; Wirth, T. Selenium-Mediated Synthesis of Tetrasubstituted Naphthalenes through Rearrangement. Molecules 2015, 20 (6), 10866-10872.

Stasyuk, A. J.; Smoleń, S.; Glodkowska-Mrowka, E.; Brutkowski, W.; Cyrański, M. K.; Tkachenko, N.; Gryko, D. T. Synthesis of Fluorescent Naphthoquinolizines via Intramolecular Houben-Hoesch Reaction. Chem. Asian J. 2015, 10 (3), 553-558.

Altri riferimenti

Beilstein
3721682
Codice tariffe armonizzato
2917.19
TSCA
No

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