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Hydroxyurea is used as an inhibitor of DNA synthesis and an anti-cancer drug. It is used as a precursor to prepare 1-hydroxy-5,6-dimethyl-1H-pyrimidine-2,4-dione via reaction with 2-methyl-3-oxo-butyric acid ethyl ester. It is used in the treatment of melanoma, resistant chronic myelocytic leukemia and recurrent metastatic or inoperable ovarian. It is also involved in reducing the rate of painful attacks in sickle-cell disease and has anti-retroviral properties in diseases such as AIDS.
Sheehan, V. A.; Nelson, S.; Yappan, C.; Dinu, B. R.; Guffey, D.; Minard, C. G.; Ware, R. E. Hydroxyurea Improves Oxygen Transport Effectiveness in Sickle Cell Anemia Patients. Blood 2014, 121 (24), 2716-2716.
Anele, U. A.; Mack, A. K.; Resar, L. M.; Burnett, A. L. Hydroxyurea therapy for priapism prevention and erectile function recovery in sickle cell disease: a case report and review of the literature. Int Urol Nephrol 2014, 46 (9), 1733-1736.
Dichiarazioni di rischio (UE): H340-H360
May cause genetic defects. May damage fertility or the unborn child.
Dichiarazioni precauzionali: P260-P201-P280-P304+P340-P405-P501a
Do not breathe dust/fume/gas/mist/vapours/spray. Obtain special instructions before use. Wear protective gloves/protective clothing/eye protection/face protection. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.