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628-13-7 - Pyridine hydrochloride, 98% - Pyridinium chloride - A10871 - Alfa Aesar

A10871 Pyridine hydrochloride, 98%

Codice CAS
628-13-7
Sinonimi
Pyridinium chloride

Dimensioni Prezzo ($) Quantità Disponibilità
50g 21,22
250g 65,10
1000g 196,43
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Pyridine hydrochloride, 98%

MDL
MFCD00012802
EINECS
211-027-4

Proprietà chimiche

Formula
C5H5N•HCl
Peso formula
115.56
Punto di fusione
ca 145°
Punto di ebollizione
222-224°
Sensibilità
Hygroscopic
Solubilità
Soluble in water (85 g/100 ml) and methanol.

Applicazioni

Pyridine hydrochloride is a classical reagent for cleavage of aryl methyl ethers at 200-220o. It is also used in the demethylation of 4,5-dimethyl-7-methoxy-1-tetralone.

Note

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. It is hygroscopic in nature.

Letteratura

William G. Dauben.; Gerhard J. Fonken. Trofimov. Isomerization of Isospirostans to Furostenols with Pyridine Hydrochloride as the Catalyst. J. Am. Chem. Soc. 1954, 76, (18), 4618-4619.

T. S. Hamilton.; Roger Adams. Reduction Of Pyridine Hydrochloride And Pyridonium Salts By Means Of Hydrogen And Platinum-Oxide Platinum Black. XVIII1. J. Am. Chem. Soc. 1928, 50, (8), 2260-2263.

Classical reagent for cleavage of aryl methyl ethers at 200-220 o : Ber ., 75, 445 (1942), avoiding the strongly acidic or basic conditions of some alternative methods; see, e.g.: J. Org. Chem., 27, 4660 (1962):

Demethylation of methyl aryl ethers can also be carried out under solvent-free conditions with microwave irradiation: J. Chem. Res. (Synop.), 394 (1999).

Epoxides at ambient temperature in chloroform give chlorohydrins: Synth. Commun., 11, 287 (1981).

In DMF, has been used for the conversion of alkyl tosylates to chlorides at room temperature: J. Am. Chem. Soc., 80, 2726 (1958).

Cleaves N-trityl groups from histidine residues in peptide synthesis: Tetrahedron Lett., 28, 6031 (1987).

Mild acid catalyst, e.g. in the formation of acetals with ethylene glycol: J. Org. Chem., 31, 26 (1966), or 1,3-propanediol: Bull. Soc. Chim. Fr., 2287 (1972); and in the Fischer indole synthesis for acid-sensitive substrates: Synthesis, 645 (1977).

Rischio GHS e dichiarazioni precauzionali

Dichiarazioni di rischio (UE): H302-H315-H319-H335

Harmful if swallowed. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Dichiarazioni precauzionali: P261-P280-P305+P351+P338-P304+P340-P362-P301+P312-P312-P405-P403+P233-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Altri riferimenti

Beilstein
3615340
Codice tariffe armonizzato
2933.31
TSCA
Yes
RTECS
UT4375000

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