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L-serine is used as a dietary supplement to improve health under certain conditions of malnutrition or physical stress, as a cosmetic incredient, as ingredients for cell culture media. It is used as a precursor to several amino acids, including glycine, cysteine and other metabolites such as sphingolipids and folate. It is used in bio-synthesis of purines and pyrimidines. It plays a vital role in catalytic function of enzymes. Further, L-serine and its metabolic products are essential for cell proliferation and specific functions of the central nervous system. .
Has been used in a synthesis of D-amino acids. The configuration is inverted by conversion of the carboxyl group to the new alkyl chain by reaction with an organolithium reagent to give the ketone, which is deoxygenated by Raney nickel desulfurization of the thioketal, the hydroxymethyl group becoming the new carboxyl group by oxidation with oxygen over a Pt catalyst: J. Am. Chem. Soc., 106, 1095 (1984):
Sim, W. C.; Yin, H. Q.; Choi, H. S.; Choi, Y. J.; Kwak, H. C.; Kim, S. K.; Lee, B. H. l-Serine Supplementation Attenuates Alcoholic Fatty Liver by Enhancing Homocysteine Metabolism in Mice and Rats. J. Nutr. 2015, 145 (2), 260-267.
Zafarani-Moattar, M. T.; Asadzadeh, B. Effect of 1-carboxymethyl-3-methylimidazolium chloride,[HOOCMMIM][Cl], ionic liquid on volumetric, acoustic and transport behavior of aqueous solutions of l-serine and l-threonine at T= 298.15 K. J. Mol. Liq. 2015, 202, 79-85.