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59-92-7 - 3,4-Dihydroxy-L-phenylalanine, 98+% - L-DOPA - 3-Hydroxy-L-tyrosine - A11311 - Alfa Aesar

A11311 3,4-Dihydroxy-L-phenylalanine, 98+%

Codice CAS
59-92-7
Sinonimi
L-DOPA
3-Hydroxy-L-tyrosine

Dimensioni Prezzo ($) Quantità Disponibilità
5g 31,60
25g 105,00
100g 350,00
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3,4-Dihydroxy-L-phenylalanine, 98+%

MDL
MFCD00002598
EINECS
200-445-2

Proprietà chimiche

Formula
C9H11NO4
Peso formula
197.19
Punto di fusione
ca 295° dec.
Solubilità
Slightly soluble in water, dilute hydrochloric acid and formic acid. Insoluble in ethanol.

Applicazioni

3,4-dihydroxy-L-phenylalanine (DOPA) is used as a cell adhesion molecule in serum-free cultures of anchorage-dependent mammalian cells. It is also used as an anticholinergic drug and used in the treatment of Parkinson's disease. It acts as an intermediate in the biosynthesis of other catecholamines (norepinephrine, epinephrine) and melanin. It acts as a precursor of dopamine product of tyrosine hydroxylase.

Note

Incompatible with strong oxidizing agents.

Letteratura

Fichman, G.; Adler-Abramovich, L.; Manohar, S.; Mironi-Harpaz, I.; Guterman, T.; Seliktar, D.; Messersmith, P. B.; Gazit, E. Seamless Metallic Coating and Surface Adhesion of Self-Assembled Bioinspired Nanostructures Based on Di-(3,4-dihydroxy-l-phenylalanine) Peptide Motif. ACS Nano. 2014, 8 (7), 7220-7228.

Huang, Y.; Han, Q.; Zhang, Q.; Guo, L.; Guo, D.; Yingzi Fu, Y. A fast chiral sensing to DOPA enantiomers via poly-lysine films matrixes. Electrochim. Acta. 2013, 113, 564-569.

Yue, Q.; Wang, M.; Sun, Z.; Wang, C.; Wang, C.; Deng, Y.; Zhao, D. A versatile ethanol-mediated polymerization of dopamine for efficient surface modification and the construction of functional core-shell nanostructures. J. Mater. Chem. B 2013, 1 (44), 6085-6093.

Xiong, S.; Wang, Y.; Zhu, J.; Yu, J.; Hu, Z. Mussel-Adhesive-Inspired Fabrication of Multifunctional Silver Nanoparticle Assemblies. Langmuir 2015, 31 (19), 5504-5512.

Matin, M. A.; Chitumalla, R. K.; Lim, M.; Gao, X.; Jang, J. Density Functional Theory Study on the Cross-Linking of Mussel Adhesive Proteins. J. Phys. Chem. B 2015, 119 (17), 5496-5504.

Rischio GHS e dichiarazioni precauzionali

Dichiarazioni di rischio (UE): H302

Harmful if swallowed.

Dichiarazioni precauzionali: P260-P201-P280-P304+P340-P405-P501a

Do not breathe dust/fume/gas/mist/vapours/spray. Obtain special instructions before use. Wear protective gloves/protective clothing/eye protection/face protection. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Altri riferimenti

Merck
14,5464
Beilstein
2215169
Codice tariffe armonizzato
2922.50
TSCA
Yes
RTECS
AY5600000

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