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56-05-3 - 2-Amino-4,6-dichloropyrimidine, 98% - 4,6-Dichloro-2-pyrimidinamine - A11330 - Alfa Aesar

A11330 2-Amino-4,6-dichloropyrimidine, 98%

Codice CAS
56-05-3
Sinonimi
4,6-Dichloro-2-pyrimidinamine

Dimensioni Prezzo ($) Quantità Disponibilità
5g 43,67
25g 138,02
100g 436,72
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2-Amino-4,6-dichloropyrimidine, 98%

MDL
MFCD00006090
EINECS
200-253-9

Proprietà chimiche

Formula
C4H3Cl2N3
Peso formula
164.00
Punto di fusione
218-222°
Solubilità
Insoluble in water, soluble in acetone, two monomer (VCM) and thermal toluene.

Applicazioni

Microwave-assisted synthesis of pyrazolo [3, 4-d] pyrimidines from 2-amino-4, 6-dichloropyrimidine-5-carbaldehyde is under solvent-free conditions. A series of 6-alkynyl-2,4-diaminopyrimidine derivatives bearing various substituents at alkynyl moiety was prepared by the Sonogashira cross-coupling reaction of 2,4-diamino-6-iodopyrimidine using Pd(PPh3)2Cl2 as catalyst.

Note

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store away from strong oxidizing agents.

Letteratura

Dana Hocková,; Antonı?n Holý,; Milena Masojı?dková,; Ivan Votruba. An efficient synthesis of cytostatic mono and bis-alkynylpyrimidine derivatives by the Sonogashira cross-coupling reactions of 2,4-diamino-6-iodopyrimidine and 2-amino-4,6-dichloropyrimidine. Tetrahedron. 2004, 60 (23), 4983-4987.

C. J. B. Clews,; W. Cochran. The structures of pyrimidines and purines. I. A determination of the structures of 2-amino-4-methyl-6-chloropyrimidine and 2-amino-4,6-dichloropyrimidine by X-ray methods . Acta Cryst.. 1948, 14-11.

Rischio GHS e dichiarazioni precauzionali

Dichiarazioni di rischio (UE): H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Dichiarazioni precauzionali: P261-P280-P305+P351+P338-P304+P340-P362-P312-P321-P405-P403+P233-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Call a POISON CENTER or doctor/physician if you feel unwell. Specific treatment (see label). Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Altri riferimenti

Beilstein
118454
Codice tariffe armonizzato
2933.59
TSCA
Yes
RTECS
UV6260485

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