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402-31-3 - 1,3-Bis(trifluoromethyl)benzene, 98+% - alpha,alpha,alpha,alpha',alpha',alpha'-Hexafluoro-m-xylene - A11360 - Alfa Aesar

A11360 1,3-Bis(trifluoromethyl)benzene, 98+%

Codice CAS
402-31-3
Sinonimi
alpha,alpha,alpha,alpha',alpha',alpha'-Hexafluoro-m-xylene

Dimensioni Prezzo ($) Quantità Disponibilità
50g 39,80
250g 135,00
1000g 422,00
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1,3-Bis(trifluoromethyl)benzene, 98+%

MDL
MFCD00000392
EINECS
206-939-4

Proprietà chimiche

Formula
C8H4F6
Peso formula
214.11
Punto di fusione
-35°
Punto di ebollizione
115-117°
Punto di infiammabilità
26°(78°F)
Densità
1.378
Indice di rifrazione
1.3790
Solubilità
Insoluble in water. Soluble in alcohol, ether, benzene.

Applicazioni

1,3-Bis(trifluoromethyl)benzene undergoes regioselective metalation and subsequent carboxylation at position 2 to give 2,6-bis(trifluoromethyl)benzoic acid. a convenient, selective synthesis of bis[2,4-bis(trifluoromethyl)phenyl]phosphane derivatives with 1,3-bis(trifluoromethyl)benzene as starting material.

Note

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store away from strong oxidizing agents.

Letteratura

Aeberli P,; Houlihan WJ. The Metalation of 1, 3-Bis (trifluoromethyl) benzene by n butyllithium.. J. Organomet. Chem. 1974, 64 (3), 321-25.

Berthold Hoge Dr.,; Boris Kurscheid,; Sebastian Peuker,; Wieland Tyrra,; Hendrik T. M. Fischer. A Convenient, Selective Synthesis of Bis[2,4-bis(trifluoromethyl)phenyl]phosphane Derivatives Starting from 1,3-Bis(trifluoromethyl)benzene† . Zeitschrift für anorganische und allgemeine Chemie. 2007, 633 (10) ,679-1685 pg no.

Metallation with n-BuLi in diethyl ether is unselective, giving, on quenching with CO2, a mixture of 2,4- and 2,6-bis(trifluoromethyl)benzoic acids: J. Organomet. Chem., 67, 321 (1974). The superbasic n-BuLi/KO-t-Bu combination leads to almost exclusive 2-metallation, allowing the 2,6-bis(trifluoromethyl) acid to be isolated in 78% yield. In contrast, a combination of sec-BuLi and N,N,N',N',N'-pentamethyldiethylenetriamine leads to the 2,4-bis(trifluoromethyl) acid as the main product: Synlett, 747 (1990).

Rischio GHS e dichiarazioni precauzionali

Dichiarazioni di rischio (UE): H226-H315-H319-H335

Flammable liquid and vapour. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Dichiarazioni precauzionali: P260-P201-P280g-P304+P340-P405-P501a

Do not breathe dust/fume/gas/mist/vapours/spray. Obtain special instructions before use. Wear protective gloves. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Altri riferimenti

Beilstein
2052589
Classe di rischio
3
Gruppo di imballaggio
III
Codice tariffe armonizzato
2903.99
TSCA
Yes

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