Autorizzo l’utilizzo di cookies.

Accetto Utilizziamo cookies per migliorare il nostro servizio e realizzare statistiche. Questa funzione puó essere disattivata cambiando la configurazione del browser. Continuando a navigare senza modificare questi parametri, consideriamo che l’uso di cookies sia accettato

89-00-9 - Pyridine-2,3-dicarboxylic acid, 99% - Quinolinic acid - A11414 - Alfa Aesar

A11414 Pyridine-2,3-dicarboxylic acid, 99%

Codice CAS
89-00-9
Sinonimi
Quinolinic acid

Dimensioni Prezzo ($) Quantità Disponibilità
25g 22,20
100g 57,40
Aggiungi al carrello Aggiungi al preventivo generale Visualizza articolo

Pyridine-2,3-dicarboxylic acid, 99%

MDL
MFCD00006295
EINECS
201-874-8

Proprietà chimiche

Formula
C7H5NO4
Peso formula
167.12
Punto di fusione
ca 188° dec.
Solubilità
Soluble in water (partly), alkalies, dilute aqueous base, DMSO, and alcohol (slightly).

Applicazioni

Quinolinic acid is an endogenous NMDA agonist. Quinolinic acid is a metabolite of tryptophan that acts as a putative NMDA receptor agonist. Quinolinic acid is an “excitotoxic” metabolite and an agonist of N-methyl-D-aspartate receptors. properties of KYNA raise the possibility of a functional link between KYNA and QUIN in the brain which may be of relevance for an understanding of human neurodegenerative disorders. Quinolinic acid is a potent endogenous excitant at amino acid receptors in CNS.

Note

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store away from strong oxidizing agents.

Letteratura

MF Beal,; RJ Ferrante,; KJ Swartz,; NW Kowall. Chronic quinolinic acid lesions in rats closely resemble Huntington's disease. The Journal of Neuroscience,. 1991, 11(6), 1649-1659.

Dr Melvyn P. Heyes PhD,; Bruce J. Brew MD,; Alex Martin PhD,; Richard W. Price MD,; Andres M. Salazar MD.Quinolinic acid in cerebrospinal fluid and serum in HIV-1 Infection: Relationship to clinical and neurological status. Annals of Neurology. 1991 , 29 (2),202-209.

Rischio GHS e dichiarazioni precauzionali

Dichiarazioni di rischio (UE): H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Dichiarazioni precauzionali: P261-P280a-P305+P351+P338-P304+P340-P405-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Altri riferimenti

Merck
14,8073
Beilstein
137110
Codice tariffe armonizzato
2933.39
TSCA
Yes
RTECS
US7967250

Raccomandato

  • A12124

    Diphenylphosphonic azide, 97%
  • A12683

    Nicotinic acid, 99%
  • A13285

    Formic acid, 97%
  • A14409

    Pyridine-2,4-dicarboxylic acid, 98%, may cont. up to ca 10% water
  • 33369

    Sodium hypochlorite, 11-15% available chlorine

Visualizzati di recente

Prodotti chimici

Scienze della vita

Metalli e materiali

Catalizzatori

Apparecchiature di analisi e di laboratorio