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Hypoxanthine, is used as a marker for energy perturbation in hypoxia/ ischemia. The compound has been used in studies as in indicator, along with uric acid and allantoin , of in vivo free radical reactions. It has been also used in DNA studies to investigate the destabilizing effect it has on DNA duplexes containing hypoxanthine as a base, in a gas phase versus a liquid phase. Hypoxanthine has also been used in studies along with 8-oxoguanine nucleotides to investigate their interaction with human DNA pol å (DNA polymerase alpha) and DNA polymerase I from Bacillus stearothermophilus. It is also used as a pharmaceutical intermediate.
Patrick A. Limbach.; Pamela F. Crain .; James A. McCloskey. the modified nucleosides of RNA. Oxford Journals. 1994, 22, (12), 2183-2196.
James S. Chickos .; William E. Acree Jr. Enthalpies of Sublimation of Organic and Organometallic Compounds. J. Phys. Chem.. 2002, 31, 537.