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383-63-1 - Ethyl trifluoroacetate, 99% - Trifluoroacetic acid ethyl ester - A11520 - Alfa Aesar

A11520 Ethyl trifluoroacetate, 99%

Codice CAS
383-63-1
Sinonimi
Trifluoroacetic acid ethyl ester

Dimensioni Prezzo ($) Quantità Disponibilità
50g 41,60
250g 183,00
1000g 663,00
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Ethyl trifluoroacetate, 99%

MDL
MFCD00000419
EINECS
206-851-6

Proprietà chimiche

Formula
C4H5F3O2
Peso formula
142.08
Punto di fusione
<-78°
Punto di ebollizione
60-62°
Punto di infiammabilità
-1°(30°F)
Densità
1.192
Indice di rifrazione
1.3070
Sensibilità
Moisture Sensitive
Solubilità
Slightly miscible with water. Miscible with chloroform and methanol.

Applicazioni

Ethyl trifluoroacetate is used as an intermediate in organic synthesis to prepare organic fluorine compounds like 3-ethyl-1-methylimidazolium trifluoroacetate (EMITA). It is involved in the syntheses of various pharmaceutically active molecules and agricultural products. It is also useful for the preparation of tri fluoroacylated compounds.

Note

Moisture Sensitive. Keep the container tightly closed in a dry and well-ventilated place. Incompatible with strong oxidizing agents, strong bases and strong acids.

Letteratura

Reagent for selective trifluoroacetylation of amines. Primary amines can be protected in the presence of secondary, and diamines selectively monoprotected. Primary amines can also be differentiated in terms of steric hindrance: Tetrahedron Lett., 36, 7357 (1995).

Esters of perfluoroalkyl carboxylic acids undergo Wittig reactions, for example with the ylide from (3-Phenyl­propyl)­triphenyl­phosphonium bromide, A12669, leading to 1-perfluoroalkyl enol ethers, which are useful precursors of various fluorinated derivatives: J. Org. Chem., 57, 3807 (1992); Org. Synth., 75, 153 (1997):

Bhattacharjee, D.; Tiwari, L.; Singh, H. J.; Mishra, B. K.; Deka, R. C. Theoretical investigation on mechanism, kinetics and thermochemistry of gas-phase reactions of ethyl trifluoroacetate with OH radicals. J. Fluorine Chem. 2015, 178, 79-85.

Huang, Z.; Jiang, H.; Li, L.; Wang, H.; Qiu, T. Density, viscosity, and saturated vapor pressure of ethyl trifluoroacetate. J. Chem. Thermodyn. 2015, 86, 75-79.

Rischio GHS e dichiarazioni precauzionali

Dichiarazioni di rischio (UE): H225-H314-H318

Highly flammable liquid and vapour. Causes severe skin burns and eye damage. Causes serious eye damage.

Dichiarazioni precauzionali: P210-P260u-P303+P361+P353-P305+P351+P338-P405-P501a

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Altri riferimenti

Beilstein
1761411
Classe di rischio
3
Gruppo di imballaggio
II
Codice tariffe armonizzato
2915.90
TSCA
Yes

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