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103-72-0 - Phenyl isothiocyanate, 97% - A11596 - Alfa Aesar

A11596 Phenyl isothiocyanate, 97%

Codice CAS
103-72-0
Sinonimi

Dimensioni Prezzo ($) Quantità Disponibilità
5g 22,00
100g 37,30
500g 138,00
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Phenyl isothiocyanate, 97%

MDL
MFCD00004798
EINECS
203-138-1

Proprietà chimiche

Formula
C7H5NS
Peso formula
135.19
Punto di fusione
-21°
Punto di ebollizione
220-221°
Punto di infiammabilità
87°(188°F)
Densità
1.131
Indice di rifrazione
1.6500
Sensibilità
Moisture Sensitive
Solubilità
Soluble in alcohol, and ether. Insoluble in water.

Applicazioni

Phenyl isothiocyanate acts as a derivatizing reagent for primary and secondary amines. It is used in sequencing peptides by Edman degradation and in amino acid analyses by HPLC. It is used for derivatizing N-terminal amino acids of proteins for automated sequential analysis. It is a synthon for dithiadiazafulvalenes.

Note

Moisture Sensitive. Protect from humidity and water. Store under dry inert gas away from oxidizing agents and moisture. Store at 4°C.

Letteratura

F Lai; T Sheehan. Matrix effects in the derivatization of amino acids with naphthalene dicarboxaldehyde, 9-fluorenylmethyl chloroformate and phenylisothiocyanate. BioTechniques.1993, 14 (4), 642-649.

Mark C Wesley; Luis M Pereira; Laurie A Scharp; Sitaram M Emani; Francis X McGowan; James A DiNardo. Pharmacokinetics of tranexamic acid in neonates, infants, and children undergoing cardiac surgery with cardiopulmonary bypass. Anesthesiology.2015, 122 (4), 746-758.

Derivatizing agent for amino groups. Introduced by Edman for the determination of amino acid sequence by conversion to the thiourea, acid cleavage of the peptide bond and alkaline hydrolysis of the derived thiohydantoin: Acta Chem. Scand., 4, 277 (1950); Arkiv. Kemi., 14, 291 (1959). The thiourea can also be cleaved with TFA: Nature, 227, 716 (1970), or by peracid oxidation: Chem. Ber., 89, 2288 (1956).

For general reactions of isothiocyanates, see Appendix 3.

Rischio GHS e dichiarazioni precauzionali

Dichiarazioni di rischio (UE): H227-H301-H314-H318-H334-H317

Combustible liquid. Toxic if swallowed. Causes severe skin burns and eye damage. Causes serious eye damage. May cause allergy or asthma symptoms or breathing difficulties if inhaled. May cause an allergic skin reaction.

Dichiarazioni precauzionali: P210u-P301+P310a-P303+P361+P353-P305+P351+P338-P405-P501a

IF SWALLOWED: IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Altri riferimenti

Merck
14,7297
Beilstein
471392
Classe di rischio
6.1
Gruppo di imballaggio
II
Codice tariffe armonizzato
2930.90
TSCA
Yes
RTECS
NX9275000

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