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563-41-7 - Semicarbazide hydrochloride, 99% - A11668 - Alfa Aesar

A11668 Semicarbazide hydrochloride, 99%

Codice CAS
563-41-7
Sinonimi

Dimensioni Prezzo ($) Quantità Disponibilità
100g 23,40
500g 67,90
2500g 263,00
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Semicarbazide hydrochloride, 99%

MDL
MFCD00013009
EINECS
209-247-0

Proprietà chimiche

Formula
CH4N3O•HCl
Peso formula
111.53
Punto di fusione
ca 176° dec.
Solubilità
Soluble in water (>100g/L).

Applicazioni

Semicarbazide hydrochloride is used as urease substrate and MAO inhibitor. Derivatizing agent for carbonyl compounds as their semicarbazones which produces crystalline compounds with characteristic melting points. Also used in heterocyclic synthesis. Semicarbazone formation has been used to separate carbonyl compounds from mixtures by adsorption onto silica gel from a hydrocarbon solution. Regeneration is by hydrolysis with oxalic acid.

Note

Store in cool, dry conditions in well sealed container. Store away from oxidizing agent.

Letteratura

Phedias Diamandis et. al. Chemical genetics reveals a complex functional ground state of neural stem cells. Nature Chemical Biology. 2007, 3 (5), 268-273.

Fumiko Marttila-Ichihara; Karolien Castermans; Kaisa Auvinen; Mirjam G A Oude Egbrink; Sirpa Jalkanen; Arjan W Griffioen; Marko Salmi. Small-molecule inhibitors of vascular adhesion protein-1 reduce the accumulation of myeloid cells into tumors and attenuate tumor growth in mice. Journal of Immunology. 2010, 184 (6), 3164-3173.

Derivatizing agent for carbonyl compounds as their semicarbazones. Also used in heterocyclic synthesis. Semicarbazone formation has been used to separate carbonyl compounds from mixtures by adsorption onto silica gel from a hydrocarbon solution. Regeneration is by hydrolysis with oxalic acid: Tetrahedron, 37, 843 (1981).

Other reagents for the cleavage of semicarbazones include: Amberlyst® 15 in aqueous acetone: J .Chem. Soc., Perkin 1, 2563 (1988); Dowex® 50 in aqueous suspension: J. Org. Chem., 53, 878 (1988); CuSO4 in aqueous THF: J. Prakt. Chem., 322 1063 (1980).

Rischio GHS e dichiarazioni precauzionali

Dichiarazioni di rischio (UE): H301-H315-H319-H335

Toxic if swallowed. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Dichiarazioni precauzionali: P261-P280a-P301+P310a-P305+P351+P338-P405-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF SWALLOWED: Immediately call a POISON CENTER/doctor IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Altri riferimenti

Merck
14,8444
Beilstein
3593642
Classe di rischio
6.1
Gruppo di imballaggio
III
Codice tariffe armonizzato
2928.00
TSCA
Yes
RTECS
VT3500000

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