Informativa e consenso per l'uso dei cookie

Accetto Il nostro sito salva piccoli pezzi di informazioni (cookie) sul dispositivo, al fine di fornire contenuti migliori e per scopi statistici. È possibile disattivare l'utilizzo di cookies modificando le impostazioni del tuo browser. Continuando la navigazione si acconsente all'utilizzo dei cookie.

773-64-8 - Mesitylene-2-sulfonyl chloride, 99% - 2,4,6-Trimethylbenzenesulfonyl chloride - A11775 - Alfa Aesar

A11775 Mesitylene-2-sulfonyl chloride, 99%

Codice CAS
773-64-8
Sinonimi
2,4,6-Trimethylbenzenesulfonyl chloride

Dimensioni Prezzo ($) Quantità Disponibilità
25g 54,00
100g 149,00
500g 525,00
Aggiungi al carrello Aggiungi al preventivo generale Visualizza articolo

Mesitylene-2-sulfonyl chloride, 99%

MDL
MFCD00007434
EINECS
212-257-8

Proprietà chimiche

Formula
C9H11ClO2S
Peso formula
218.70
Punto di fusione
53-57°
Punto di ebollizione
150°/20mm
Punto di infiammabilità
>110°(230°F)
Sensibilità
Moisture Sensitive
Solubilità
Soluble in toluene (almost transparency).

Applicazioni

Mesitylene-2-sulfonyl chloride is used as reagent for intramolecular lactamizations and lactonization. It also acts as a reagent for protecting guanidino groups and tryptophan. It is used as coupling reagent in polynucleotide synthesis

Note

Moisture Sensitive. Store under inert gas. Incompatible with strong bases. Store away from moisture.

Letteratura

Chi-Hua Wang; Saul G. Cohen. Mercaptan Catalysis in Thermoneutral Free Radical Exchange.J. Am. Chem. Soc. 1957, 79 (8),1924-1929.

Adeleh Kiania; Batool Akhlaghiniaa; Hamed Rouhi-Saadabada & Mehdi Bakavolia.Journal of Sulfur Chemistry. 2014, 35 119-127.

Selective reagent for sulfonylation of carbohydrates: J. Chem. Soc., Perkin 1, 1373 (1974).

For reviews of the use of hindered sulfonyl chlorides as condensing agents for the formation of the phosphate link of oligonucleotides, see: Angew. Chem. Int. Ed., 11, 451 (1972); Synthesis, 222 (1975); Chem. Rev., 77, 183 (1977). For reviews of oligonucleotide synthesis by the phosphotriester method, see: Heterocycles, 7, 1197 (1977); Tetrahedron, 34, 3143 (1978). Compare 2,4,6-Triisopropyl­benzenesulfonyl­ chloride, A11458.

Reagent for protection of the guanidino function of arginine residues as mesitylenesulfonyl (Mts) derivatives in peptide synthesis: J. Chem. Soc., Chem. Commun., 482 (1978); Chem. Pharm. Bull., 26, 3752 (1978); Int. J. Pept. Prot. Res., 14, 169 (1979). Deprotection can be effected with triflic acid in TFA in the presence of thioanisole as a cation scavenger: J. Chem. Soc., Chem. Commun., 1063 (1980).

The indole nitrogen, e.g. in tryptophan residues, may also be protected as the Mts amide, stable to dilute alkali, hydrazine hydrate, TFA, 4N HCl in dioxane, or HBr in AcOH, but cleaved by MsOH, or TfOH in TFA: Chem. Pharm. Bull., 32, 2660 (1984). See Appendix 6.

Rischio GHS e dichiarazioni precauzionali

Dichiarazioni di rischio (UE): H314-H318

Causes severe skin burns and eye damage. Causes serious eye damage.

Dichiarazioni precauzionali: P260-P280-P303+P361+P353-P305+P351+P338-P301+P330+P331-P304+P340-P310-P363-P405-P501a

Do not breathe dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Immediately call a POISON CENTER or doctor/physician. Wash contaminated clothing before reuse. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Altri riferimenti

Beilstein
1107601
Classe di rischio
8
Gruppo di imballaggio
II
Codice tariffe armonizzato
2904.90
TSCA
No
RTECS
DB8930000

Raccomandato

  • A10776

    Trimethylacetic acid, 99%
  • A10973

    N,N'-Dicyclohexylcarbodiimide, 99%
  • A11006

    Ethyl N-hydroxyacetimidate, 97%
  • A11307

    2,3-Dihydroxynaphthalene, 98%
  • A11458

    2,4,6-Triisopropylbenzenesulfonyl chloride, 98%

Visualizzati di recente

Prodotti chimici

Scienze della vita

Metalli e materiali

Catalizzatori

Apparecchiature di analisi e di laboratorio