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707-61-9 - 3-Methyl-1-phenyl-2-phospholene 1-oxide, 94% - A11792 - Alfa Aesar

A11792 3-Methyl-1-phenyl-2-phospholene 1-oxide, 94%

Codice CAS
707-61-9
Sinonimi

Dimensioni Prezzo ($) Quantità Disponibilità
5g 57,30
25g 202,00
100g 680,00
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3-Methyl-1-phenyl-2-phospholene 1-oxide, 94%

MDL
MFCD00014518
EINECS
211-901-5

Proprietà chimiche

Formula
C11H13OP
Peso formula
192.19
Punto di fusione
60-65°
Punto di ebollizione
173-174°/0.7mm
Sensibilità
Hygroscopic
Solubilità
Soluble in polar solvents.

Applicazioni

3-Methyl-1-phenyl-2-phospholene 1-oxide is used as a catalyst for intramolecular aza-wittig cyclization reactions and polymerization reactions. It is a reactant used for the preparation of phospha sugars and their radical bromination derivatives as anticancer agents.

Note

Hygroscopic. Incompatible with strong oxidizing agents.

Letteratura

(previously believed to have the double bond in the 3-position)

Catalyst for conversion of isocyanates to carbodiimides: Org. Synth. Coll., 5, 501 (1973).

Makita, R.; Yamashita, M.; Yamaoka, M.; Fuije, M.; Nakamura, S.; Oshikawa, T.; Yamashita, J.; Yamada, M.; Asai, K.; Suyama, T.; Kondo, M.; Hasegawa, H.; Okita, Y.; Hirakawa, K.; Toda, M.; Ohnishi, K.; Sugimura, H. Novel Multiple Type Molecular Targeted Antitumor Agents: Preparation and Preclinical Evaluation of Low-Molecular-Weight Phospha Sugar Derivatives. Phosphorus Sulfur 2015, 190 (5-6), 733-740.

Hu, G.; Gao, Y.; Zhao, Y. Copper-Catalyzed Decarboxylative C-P Cross-Coupling of Alkynyl Acids with H-Phosphine Oxides: A Facile and Selective Synthesis of (E)-1-Alkenylphosphine Oxides. Org. Lett. 2015, 16 (17), 4464-4467.

Rischio GHS e dichiarazioni precauzionali

Dichiarazioni di rischio (UE): H302

Harmful if swallowed.

Dichiarazioni precauzionali: P260-P201-P280-P304+P340-P405-P501a

Do not breathe dust/fume/gas/mist/vapours/spray. Obtain special instructions before use. Wear protective gloves/protective clothing/eye protection/face protection. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Altri riferimenti

Beilstein
609223
Codice tariffe armonizzato
2934.99
TSCA
Yes
RTECS
SZ6105100

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