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327-52-6 - 1-Bromo-2,4,5-trifluorobenzene, 98+% - 2,4,5-Trifluorobromobenzene - A11962 - Alfa Aesar

A11962 1-Bromo-2,4,5-trifluorobenzene, 98+%

Codice CAS
327-52-6
Sinonimi
2,4,5-Trifluorobromobenzene

Dimensioni Prezzo ($) Quantità Disponibilità
1g 19,20
5g 45,40
25g 180,00
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1-Bromo-2,4,5-trifluorobenzene, 98+%

MDL
MFCD00000306
EINECS
206-318-8

Proprietà chimiche

Formula
C6H2BrF3
Peso formula
210.98
Punto di fusione
-19°
Punto di ebollizione
143-144°
Punto di infiammabilità
55°(131°F)
Densità
1.806
Indice di rifrazione
1.4860
Solubilità
Insoluble in water.

Applicazioni

1-Bromo-2,4,5-trifluorobenzene is the intermediate of liquid crystals. The derivatives of this compound can be used as intermediates for the synthesis of qunolone antibacterial. It is employed in the synthesis of 3-ethenyl, 3-ethynyl, 3-aryl, and 3-cyclopropyl-2, 4, 5-trifluorobenzoic acids from 1-bromo-2, 4, 5-trifluorobenzene and 2, 4, 5-trifluoro-3-hydroxybenzoic acid.

Note

Store at room temperature. Keep away from oxidizing agents.

Letteratura

William R. Turner.; Mark J. Suto. 3-Ethenyl, 3-ethynyl, 3-aryl, and 3-cyclopropyl-2,4,5-trifluorobenzoic acids: Useful intermediate in the synthesis of quinolone antibacterials. Tetrahedron Lett. 1993, 34 (2),281-284.

H.-J. Frohn.; H. Franke.; P. Fritzen.; V.V. Bardin. (Fluoroorgano)fluoroboranes and -fluoroborates I: synthesis and spectroscopic characterization of potassium fluoroaryltrifluoroborates and fluoroaryldifluoroboranes. J. Organomet. Chem. 2000, 598 (1),127-135.

Lithiation with LDA occurs selectively at the 3-position, and has been exploited in the synthesis of 8-(trifluoromethyl)-substituted quinolines as antibacterial agents: J. Med. Chem., 35, 361 (1992). For a study of lithiation under various conditions, see: J. Chem. Soc., Perkin 1, 2729 (1995).

Rischio GHS e dichiarazioni precauzionali

Dichiarazioni di rischio (UE): H226-H315-H319-H335

Flammable liquid and vapour. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Dichiarazioni precauzionali: P210-P261-P280-P240-P303+P361+P353-P305+P351+P338-P304+P340-P362-P405-P501a

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. Ground/bond container and receiving equipment. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Altri riferimenti

Beilstein
1636588
Classe di rischio
3
Gruppo di imballaggio
III
Codice tariffe armonizzato
2903.99
TSCA
No

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