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25561-30-2 - N,O-Bis(trimethylsilyl)trifluoroacetamide, 98+% - BSTFA - A12033 - Alfa Aesar

A12033 N,O-Bis(trimethylsilyl)trifluoroacetamide, 98+%

Codice CAS
25561-30-2
Sinonimi
BSTFA

Dimensioni Prezzo ($) Quantità Disponibilità
5g 26,06
10g 34,11
50g 129,78
100g 272,38
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N,O-Bis(trimethylsilyl)trifluoroacetamide, 98+%

MDL
MFCD00008269
EINECS
247-103-9

Proprietà chimiche

Formula
C8H18F3NOSi2
Peso formula
257.40
Punto di fusione
-10°
Punto di ebollizione
145-147°
Punto di infiammabilità
23°(73°F)
Densità
0.97
Indice di rifrazione
1.3840
Sensibilità
Moisture Sensitive
Solubilità
Miscible with chloroform.

Applicazioni

N,O-Bis(trimethylsilyl)trifluoroacetamide is used as a derivatization reagent for gas chromatography and mass-spectrometry analysis of phenolic acids in fruits. It is also used as a reactant in the preparation of pyrimidinone ribosides and analogs which shows anti-tumor properties. It plays as an important role as a reagent for the regioselective desulfation of polysaccharide sulfates. Furthermore, it is used to prepare trimethylsilyl ethers of carbohydrates and alcohols.

Note

Moisture sensitive. Store in cool place. Keep the container tightly closed in a dry and well-ventilated place Incompatible with strong oxidizing agents and strong acids.

Letteratura

Powerful silylation reagent useful in GC and GC-MS for the derivatization of a wide range of functional groups under mild conditions, similar to N,O-Bis(trimethyl­silyl)­acetamide, L00183, with the advantage that both the reagent and its by-product, trifluoroacetamide, are more volatile than the corresponding non-fluorinated analogues: Biochem. Biophys. Res. Commun., 31, 616 (1968). See Appendix 4.

Sagona, J. A.; Dukett, J. E.; Hawley, H. A.; Mazurek, M. A. Sequential derivatization of polar organic compounds in cloud water using O-(2, 3, 4, 5, 6-pentafluorobenzyl) hydroxylamine hydrochloride, N, O-bis (trimethylsilyl) trifluoroacetamide, and gas-chromatography/mass spectrometry analysis. J. Chromatogr. A 2014, 1362, 16-24.

Irei, S.; Rudolph, J.; Huang, L. Compound-specific stable carbon isotope ratios of phenols and nitrophenols derivatized with N, O-bis (trimethylsilyl) trifluoroacetamide. Anal. Chim. Acta 2013, 786, 95-102.

Rischio GHS e dichiarazioni precauzionali

Dichiarazioni di rischio (UE): H314-H318-H226

Causes severe skin burns and eye damage. Causes serious eye damage. Flammable liquid and vapour.

Dichiarazioni precauzionali: P210-P260-P280-P303+P361+P353-P305+P351+P338-P301+P330+P331-P304+P340-P310-P405-P501a

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Do not breathe dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Immediately call a POISON CENTER or doctor/physician. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Altri riferimenti

Beilstein
3607620
Classe di rischio
3
Gruppo di imballaggio
III
Codice tariffe armonizzato
2931.90
TSCA
No

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