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Dimethylamine hydrochloride is used as an intermediate in the manufacture of pharmaceuticals like ranitidine and metformin, tramadol and amlodipine. It is used as a precursor of atrazine. It is associated with sodium acetate and used to carry out the Willgerodt- Kindler reaction to prepare amides. Its free base reacts with carbon disulfide to get dimethyldithiocarbamate which is used in rubber vulcanization. It is involved in the synthesis of dimethyl-(1-methyl-pyrrol-2-ylmethyl)-amine by reacting with 1-methyl pyrrole and formaldehyde.
Chloride source giving a high degree of stereoselectivity in the ring opening of epoxy alcohols mediated by Titanium(IV) isopropoxide, A13703: Chem. Lett., 357 (1989).
The Willgerodt reaction can be carried out at steam-bath temperature by the use of dimethylamine hydrochloride and sodium acetate in DMF in place of Morpholine, A10355: Synthesis, 730 (1983).
Reductive amination of aldehydes and ketones occurs with titanium isopropoxide followed by sodium borohydride, giving a convenient route to N,N-dimethylated tertiary amines: J. Org. Chem., 60, 4928 (1995).
Nortcliffe, A.; Moody, C. J. Seven-membered ring scaffolds for drug discovery: Access to functionalised azepanes and oxepanes through diazocarbonyl chemistry. Bioorg Med Chem 2015, 23 (11), 2730-2735.
Lan, J. S.; Pan, L. F.; Xie, S. S.; Wang, X. B.; Kong, L. Y. Synthesis and evaluation of 6-methylcoumarin derivatives as potent and selective monoamine oxidase B inhibitors. Med. Chem. Commun. 2015, 6 (4), 592-600.
Dichiarazioni di rischio (UE): H302-H315-H319-H335
Harmful if swallowed. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Dichiarazioni precauzionali: P261-P280a-P305+P351+P338-P304+P340-P405-P501a
Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.