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6112-76-1 - 6-Mercaptopurine monohydrate, 98% - 6-Purinethiol monohydrate - A12197 - Alfa Aesar

A12197 6-Mercaptopurine monohydrate, 98%

Codice CAS
6112-76-1
Sinonimi
6-Purinethiol monohydrate

Dimensioni Prezzo ($) Quantità Disponibilità
1g 20,50
5g 61,50
25g 226,00
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6-Mercaptopurine monohydrate, 98%

MDL
MFCD03854445
EINECS
200-037-4

Proprietà chimiche

Formula
C5H4N4S•H2O
Peso formula
170.19 (152.17anhy)
Punto di fusione
ca 315° dec.
Solubilità
Soluble in dilute solutions of alkali hydroxides, hot alcohol, and 1 N NaOH (50 mg/ml). Insoluble in water.

Applicazioni

6-Mercaptopurine is a widely used antileukemic agent that inhibits de novopurine synthesis through incorporation of thiopurine methyltransferase metabolites into DNA and RNA. It is also an antitumor agent and induces apoptosis.

Note

Store in cool, dry place, in well sealed container. Store away from oxidizing agents.

Letteratura

K. D. Senali Abayratna Wansa; Jonathan M. Harris; Grace Yan; Peter Ordentlich and George E. O. Muscat. The AF-1 Domain of the Orphan Nuclear Receptor NOR-1 Mediates Trans-activation, Coactivator Recruitment, and Activation by the Purine Anti-metabolite 6-Mercaptopurine. The Journal of Biological Chemistry. 1986, 278, 24776-24790.

John A. Montgomery; Thomas P. Johnston; Anne Gallagher; Carl R. Stringfellow; Frank M. SchabelJr. A Comparative Study of the Anticancer Activity of Some S-Substituted Derivatives of 6-Mercaptopurine and their Ribonucleosides. J. Med. Chem. 1960, 3 (2), 265-288.

Rischio GHS e dichiarazioni precauzionali

Dichiarazioni di rischio (UE): H302-H341-H361

Harmful if swallowed. Suspected of causing genetic defects. Suspected of damaging fertility or the unborn child.

Dichiarazioni precauzionali: P201-P280-P301+P312a-P308+P313-P405-P501a

Obtain special instructions before use. Wear protective gloves/protective clothing/eye protection/face protection. IF SWALLOWED: IF exposed or concerned: Get medical advice/attention. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Altri riferimenti

Merck
14,5871
Beilstein
4012091
Codice tariffe armonizzato
2933.59
TSCA
No
RTECS
UP0400000

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