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2226-96-2 - 4-Hydroxy-TEMPO, free radical, 98+% - 4-Hydroxy-2,2,6,6-tetramethyl-1-piperidin-1-yloxy, free radical - A12497 - Alfa Aesar

A12497 4-Hydroxy-TEMPO, free radical, 98+%

Codice CAS
4-Hydroxy-2,2,6,6-tetramethyl-1-piperidin-1-yloxy, free radical

Dimensioni Prezzo ($) Quantità Disponibilità
1g 25,10
5g 67,00
25g 261,00
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4-Hydroxy-TEMPO, free radical, 98+%


Proprietà chimiche

Peso formula
Punto di fusione
Punto di infiammabilità
Soluble in water, ethanol, methanol and dimethyl sulfoxide.


Superoxide scavenger with neuroprotective, anti-inflammatory and analgesic effects4-Hydroxy-TEMPO free radical is used as a catalyst and a chemical oxidant by virtue of being a stable radical. It is used for detoxifying reactive oxygen species in medicinal chemistry. It is involved in the catalysis of disproportionation of superoxide and facilitates hydrogen peroxide metabolism. It is used to prepare tris(2,2,6,6-tetramethyl-1-oxyl-4-piperidyloxy)trimellitate by reacting with benzene-1,2,4-tricarbonyl trichloride. Further, it is used as a free radical scavenger and exhibits neuroprotective, anti-inflammatory and analgesic effects. In addition to this, it has good inhibition effect to acrylic acid esters, methyl acrylate, acrylic acid, acrylonitrile, styrene and butadiene.


Store in a cool place. Incompatible with strong oxidizing agents.


Reviews: Synthesis and reactions of stable nitroxyl radicals: Synthesis, 190, 401 (1971); Advances in the chemistry of nitroxide spin labels: Chem. Rev., 78, 37 (1978); Recent advances in the chemistry of nitroxides and their applications in spin labelling: J. Sci. Ind. Res., 54, 623 (1995). For a brief feature on derived oxoammonium salts, see: Synlett, 1757 (2003).

Compare also 4-Acetamido-TEMPO, B23456 and TEMPO, A12733.

Recommended as a stabilizer (antioxidant) for the protection of unsaturated fatty acids and their derivatives: J. Am. Chem. Soc., 101, 6748 (1979).

żamoj?, K.; Wiczk, W.; Zaborowski, B.; Jacewicz, D.; Chmurzyński, L. Analysis of Fluorescence Quenching of Coumarin Derivatives by 4-Hydroxy-TEMPO in Aqueous Solution. J. Fluoresc. 2014, 24 (3), 713-718.

żamoj?, K.; Zdrowowicz, M.; Wiczk, W.; Jacewicz, D.; Chmurzyński, L. Dihydroxycoumarins as highly selective fluorescent probes for the fast detection of 4-hydroxy-TEMPO in aqueous solution. RSC Adv. 2015, 5 (78), 63807-63812.

Sunkaria, A.; Sharma, D. R.; Wani, W. Y.; Gill, K. D. Attenuation of Dichlorvos-Induced Microglial Activation and Neuronal Apoptosis by 4-Hydroxy TEMPO. Mol. Neurobiol. 2014, 49 (1), 163-175.

Rischio GHS e dichiarazioni precauzionali

Dichiarazioni di rischio (UE): H302-H315-H318-H335

Harmful if swallowed. Causes skin irritation. Causes serious eye damage. May cause respiratory irritation.

Dichiarazioni precauzionali: P260u-P201-P280-P303+P361+P353-P305+P351+P338-P301+P330+P331-P304+P340-P310a-P405-P501a

Obtain special instructions before use. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

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