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792-74-5 - Dimethyl biphenyl-4,4'-dicarboxylate, 98% - Biphenyl-4'4-dicarboxylic acid dimethyl ester - A12556 - Alfa Aesar

A12556 Dimethyl biphenyl-4,4'-dicarboxylate, 98%

Codice CAS
792-74-5
Sinonimi
Biphenyl-4'4-dicarboxylic acid dimethyl ester

Dimensioni Prezzo ($) Quantità Disponibilità
1g 49,80
5g 189,00
25g 745,00
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Dimethyl biphenyl-4,4'-dicarboxylate, 98%

MDL
MFCD00017201
EINECS
212-341-4

Proprietà chimiche

Formula
C16H14O4
Peso formula
270.29
Punto di fusione
212-216°
Solubilità
Insoluble in water.

Applicazioni

Dimethyl biphenyl-4,4'-dicarboxylate is used as a hepatoprotectant in the treatment of chronic hepatitis. At 250 µg/ml, it has been shown to stimulate JAK/STAT signaling and to induce the expression of interferon-α stimulated genes in a HepG2 cell line. It has been used to study hepatic fibrosis and chronic hepatocellular damage. It appears to normalize alanine aminotransferase (ALT) in cases where levels of ALT are elevated. It may be employed as starting reagent for the synthesis of dimethyl 2-fluoro-and 2,2?-difluorobiphenyl-4,4?-dicarboxylates.

Note

Stable under recommended storage conditions. Incompatible with oxidizing agents.

Letteratura

Seong Soo Joo; Tae Joon Won; Min Jung Kim; Kwang  Woo Hwang; Do Ik Lee. Interferon signal transduction of biphenyl dimethyl dicarboxylate/amantadine and anti-HBV activity in HepG2 2.2.15. Archives of Pharmacal Research. 2006, 29, (5)405-411

V.K. Ol’khovik; A.A.Pap; V.A.Vasilevskii; N.A.Galinovskii; S.N.Tereshko. Synthesis and properties of luminophores derived from fluorinated biphenyls. Russian Journal of Organic Chemistry. 2008, 44, (8)1172-1179

Altri riferimenti

Beilstein
2055852
Codice tariffe armonizzato
2917.39
TSCA
Yes

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