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Dimethyl biphenyl-4,4'-dicarboxylate is used as a hepatoprotectant in the treatment of chronic hepatitis. At 250 µg/ml, it has been shown to stimulate JAK/STAT signaling and to induce the expression of interferon-α stimulated genes in a HepG2 cell line. It has been used to study hepatic fibrosis and chronic hepatocellular damage. It appears to normalize alanine aminotransferase (ALT) in cases where levels of ALT are elevated. It may be employed as starting reagent for the synthesis of dimethyl 2-fluoro-and 2,2?-difluorobiphenyl-4,4?-dicarboxylates.
Seong Soo Joo; Tae Joon Won; Min Jung Kim; Kwang Woo Hwang; Do Ik Lee. Interferon signal transduction of biphenyl dimethyl dicarboxylate/amantadine and anti-HBV activity in HepG2 2.2.15. Archives of Pharmacal Research. 2006, 29, (5)405-411
V.K. Olkhovik; A.A.Pap; V.A.Vasilevskii; N.A.Galinovskii; S.N.Tereshko. Synthesis and properties of luminophores derived from fluorinated biphenyls. Russian Journal of Organic Chemistry. 2008, 44, (8)1172-1179