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345909-35-5 - 4-Hydroxyquinoline-2-carboxylic acid hydrate, 98% - Kynurenic acid - A12602 - Alfa Aesar

A12602 4-Hydroxyquinoline-2-carboxylic acid hydrate, 98%

Codice CAS
345909-35-5
Sinonimi
Kynurenic acid

Dimensioni Prezzo ($) Quantità Disponibilità
1g 19,28
5g 81,58
25g 354,32
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4-Hydroxyquinoline-2-carboxylic acid hydrate, 98%

MDL
MFCD00006753
EINECS
207-751-5

Proprietà chimiche

Formula
C10H7NO3•xH2O
Peso formula
189.17(anhy)
Punto di fusione
ca 275° dec.
Solubilità
Soluble in hot ethanol and water. Insoluble in ether. 

Applicazioni

Broad spectrum excitatory amino acid antagonist4-Hydroxyquinoline-2-carboxylic acid hydrate is used as an intermediate in synthetic chemistry. It acts as an antiexcitotoxic and anticonvulsant. It finds application in certain neurobiological disorders therapy.

Note

Incompatible with oxidizing agents.

Letteratura

Pesek, J.; Svoboda, J.; Sattler, M.; Bartram, S.; Boland, W. Biosynthesis of 8-hydroxyquinoline-2-carboxylic acid, an iron chelator from the gut of the lepidopteran Spodoptera littoralis. Org. Biomol. Chem. 2015, 13 (1), 178-184.

Tajti, J.; Majlath, Z.; Szok, D.; Csati, A.; Toldi, J.; Fulop, F.; Vecsei, L. Novel Kynurenic Acid Analogues in the Treatment of Migraine and Neurodegenerative Disorders: Preclinical Studies and Pharmaceutical Design. Curr. Pharm. Des. 2015, 21 (17), 2250-2258.

Rischio GHS e dichiarazioni precauzionali

Dichiarazioni di rischio (UE): H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Dichiarazioni precauzionali: P261-P280-P305+P351+P338-P304+P340-P362-P312-P321-P405-P403+P233-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Call a POISON CENTER or doctor/physician if you feel unwell. Specific treatment (see label). Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Altri riferimenti

Merck
14,5327
Beilstein
147451
Codice tariffe armonizzato
2933.49
TSCA
No
RTECS
VB2080000

Raccomandato

  • A10192

    Quinaldic acid, 98%
  • A12471

    Benzo[b]thiophene-2-carboxylic acid, 98%
  • A13316

    L-Citrulline, 98%
  • L12760

    2-Amino-4-hydroxyquinoline hydrate, 97%, water ca 10%
  • L15827

    12-Molybdophosphoric acid hydrate, Mo >47.5%

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