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541-16-2 - Di-tert-butyl malonate, 98+%, stab. with potassium carbonate - Malonic acid di-tert-butyl ester - A12774 - Alfa Aesar

A12774 Di-tert-butyl malonate, 98+%, stab. with potassium carbonate

Codice CAS
541-16-2
Sinonimi
Malonic acid di-tert-butyl ester

Dimensioni Prezzo ($) Quantità Disponibilità
10g 55,50
50g 220,00
250g 897,00
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Di-tert-butyl malonate, 98+%, stab. with potassium carbonate

MDL
MFCD00008810
EINECS
208-769-6

Proprietà chimiche

Formula
C11H20O4
Peso formula
216.28
Punto di fusione
-6°
Punto di ebollizione
65-67°/1mm
Punto di infiammabilità
88°(190°F)
Densità
0.965
Indice di rifrazione
1.4190
Solubilità
It is hardly soluble in water.

Applicazioni

Di-tert-butyl malonate, is used as a pharmaceutical intermediate. it can be used to produce Diazomalonsaeure-di-tert-butylester at the ambient temperature. It will need reagents cesium carbonate, p-toluenesulfonyl azide and solvent tetrahydrofuran with the reaction time of 1 hour. T

Note

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Stable under recommended storage conditions. Keep away from strong oxidizing agents, strong bases.

Letteratura

AL McCloskey.; GS Fonken.; RW Kluiber. Di-tert-butyl Malonate. organic chemistry. 200373, (1) , 49-57.

DY Kim.;SC Huh.; SM Kim. Enantioselective Michael reaction of malonates and chalcones by phase-transfer catalysis using chiral quaternary ammonium salt. Tetrahedron Letters. 200142, (36) , 6299-6301.

Alternative to Diethyl­ malonate, A15468, permitting removal of the t-butyl groups and decarboxylation by thermolysis in the presence of mild acid: J. Am. Chem. Soc., 74, 831 (1952). In the presence of Cu(OAc)2, condenses with paraformaldehyde to form the useful electrophilic alkene, di-t-butyl methylenemalonate: J. Org. Chem., 48, 3603 (1983), which is more stable than the ethyl or methyl esters, and can be stored for some weeks at room temperature. For references to use of methylenemalonic esters in Michael addition and cycloaddition reactions, see: Org. Synth. Coll., 7, 142 (1990).

Rischio GHS e dichiarazioni precauzionali

Dichiarazioni di rischio (UE): H227-H317

Combustible liquid. May cause an allergic skin reaction.

Dichiarazioni precauzionali: P210u-P261-P280a-P363-P403+P235-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. Wash contaminated clothing before reuse. Store in a well-ventilated place. Keep cool. Dispose of contents/container in accordance with local/regional/national/international regulations.

Altri riferimenti

Merck
14,3034
Beilstein
1781766
Codice tariffe armonizzato
2917.19
TSCA
Yes

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