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It is employed in the synthesis of Schiff base ligand. It is applied as a reactant in the synthesis of LPA1R antagonists used in the inhibition of LPA-induced proliferation and contraction of normal human lung fibroblasts. Also used in the synthesis of tyrosine kinase 6 proteinase inhibitors.
Basak S, et al. Synthesis, crystal structures and fluorescence properties of two new di-and polynuclear Cd (II) complexes with N2O donor set of a tridentate Schiff base ligand.Polyhedron.,2008,27(4), 1193-1200.
Jihua Wang, et al. Antimicrobial and antioxidant activities of the root bark essential oil of Periploca sepium and its main component 2-hydroxy-4-methoxybenzaldehyde.Molecules.,2010,15(8), 5807-5817 .
I Kubo and I Kinst-Hori. 2-Hydroxy-4-methoxybenzaldehyde: a potent tyrosinase inhibitor from African medicinal plants.lanta Med.,1999,65(1), 19-22.
Condensation with t-butyl acrylate results in cyclization to t-butyl 7-methoxychromene-3-carboxylate: J. Med. Chem., 36, 3580 (1993):
With (Ethoxycarbonylmethylene)triphenylphosphorane, A12896, in N,N-diethylaniline cyclization to 7-methoxycoumarin occurs: Heterocycles, 39, 613 (1994).
Dichiarazioni di rischio (UE): H315-H319-H335
Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Dichiarazioni precauzionali: P261-P280a-P305+P351+P338-P304+P340-P405-P501a
Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.